Report of the workflow results

Author

Ellis Franklin

Published

2024-04-28

1 The results as an interactive table

2 The results as sensitivity plots

Figure 1: Sensitivity plot of clusters summarised by BMD first quartile


Figure 2: Sensitivity plot of clusters summarised by BMD median with the interquartile range as an interval

3 The top 50 most sensitive clusters

Cluster 50 - 9 transcripts (~ 25% < 1.95 μg/L)

Driver GO terms :

KEGG pathways : Retinol metabolism

Wikipathways :

Figure 3: DR curves for the 1st cluster
Figure 4: BMDplot for the 1st cluster
id BMD.zSD TF trend
cyp27c1 7.3 FALSE inc
cyp3c1_1.2 42.0 FALSE inc
cyp3c3_2.1 1.2 FALSE U
lrata 37.8 FALSE inc
lratb.2 1.9 FALSE inc
ugt1b1_1.2 3.8 FALSE dec
ugt2a7_2.2 2.5 FALSE dec
ugt2a7_3.1 1.7 FALSE dec
zgc:77938 2.9 FALSE dec
Figure 5: Table of the 1st cluster content


Cluster 66 - 4 transcripts (~ 25% < 2.06 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 6: DR curves for the 2nd cluster
Figure 7: BMDplot for the 2nd cluster
id BMD.zSD TF trend
atg3 2.2 FALSE U
pi4kaa 42.3 FALSE dec
pik3c3_1.2 3.9 FALSE inc
rab5ab 1.7 FALSE dec
Figure 8: Table of the 2nd cluster content


Cluster 49 - 4 transcripts (~ 25% < 2.58 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 9: DR curves for the 3rd cluster
Figure 10: BMDplot for the 3rd cluster
id BMD.zSD TF trend
glo1 45.4 FALSE inc
mccc2 3.0 FALSE U
sdsl 1.2 FALSE dec
tdh2 36.5 FALSE dec
Figure 11: Table of the 3rd cluster content


Cluster 17 - 32 transcripts (~ 25% < 2.64 μg/L)

Driver GO terms : lipid biosynthetic process

KEGG pathways : Steroid biosynthesis

Wikipathways : Cholesterol biosynthesis

Figure 12: DR curves for the 4th cluster
Figure 13: BMDplot for the 4th cluster
id BMD.zSD TF trend
acsl1b 2.18 FALSE dec
alox12 3.38 FALSE dec
cers5 2.59 FALSE dec
crppa 18.97 FALSE inc
cyp17a1 2.73 FALSE dec
cyp27b1 3.01 FALSE dec
dhcr7 2.41 FALSE dec
ERG28 41.26 FALSE dec
fdft1_1.2 1.49 FALSE dec
fitm1l 27.73 FALSE inc
fnta_1.2 1.88 FALSE dec
fnta_1.3 30.02 FALSE inc
gpam 30.83 FALSE dec
hmgcs1_1.2 2.98 FALSE dec
impad1 2.66 FALSE dec
insig2 36.86 FALSE dec
lss 0.49 FALSE U
nus1 28.81 FALSE dec
pisd_2.1 57.14 FALSE dec
ptdss2_1.2 22.71 FALSE dec
PYURF_1.1 7.37 FALSE inc
sc5d 2.28 FALSE dec
scap 37.09 FALSE dec
sccpdha.1 1.98 FALSE dec
scd 23.97 FALSE inc
selenoi 3.77 FALSE dec
si:dkey-205h13.1_1.2 3.42 FALSE inc
si:dkey-91i10.3 3.26 FALSE dec
st6galnac4 23.11 FALSE dec
tamm41 34.60 FALSE inc
ugt8_2.1 4.12 FALSE dec
zgc:77375 34.02 FALSE dec
Figure 14: Table of the 4th cluster content


Cluster 52 - 34 transcripts (~ 25% < 2.98 μg/L)

Driver GO terms : cellular lipid metabolic process

KEGG pathways :

Wikipathways :

Figure 15: DR curves for the 5th cluster
Figure 16: BMDplot for the 5th cluster
id BMD.zSD TF trend
abcd1_1.2 4.68 FALSE dec
acox3 3.06 FALSE dec
acsl1b 2.18 FALSE dec
alox12 3.38 FALSE dec
cers5 2.59 FALSE dec
cpt1aa_1.2 2.96 FALSE dec
crppa 18.97 FALSE inc
enpp7.1_3.1 0.84 FALSE U
fa2h_1.3 1.67 FALSE dec
fitm1l 27.73 FALSE inc
gba2_1.2 1.39 FALSE dec
gpam 30.83 FALSE dec
hexb_1.3 39.70 FALSE dec
impad1 2.66 FALSE dec
mboat2a 24.39 FALSE dec
mtmr3_2.2 17.77 FALSE dec
mtmr7a_2.1 1.61 FALSE inc
nus1 28.81 FALSE dec
pisd_2.1 57.14 FALSE dec
plcg2_1.2 4.02 FALSE dec
proca1 3.66 FALSE inc
ptdss2_1.2 22.71 FALSE dec
PYURF_1.1 7.37 FALSE inc
sccpdha.1 1.98 FALSE dec
scd 23.97 FALSE inc
selenoi 3.77 FALSE dec
si:dkey-205h13.1_1.2 3.42 FALSE inc
smpd3 49.35 FALSE dec
srd5a3 25.25 FALSE inc
st6galnac4 23.11 FALSE dec
tamm41 34.60 FALSE inc
taz_1.4 35.85 FALSE inc
ugt8_2.1 4.12 FALSE dec
zgc:77375 34.02 FALSE dec
Figure 17: Table of the 5th cluster content


Cluster 48 - 4 transcripts (~ 25% < 3.01 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 18: DR curves for the 6th cluster
Figure 19: BMDplot for the 6th cluster
id BMD.zSD TF trend
cbfa2t3_1.2 2.5 FALSE bell
ldb1b_1.2 31.6 TRUE dec
lmo1_1.1 3.2 TRUE inc
tcf3a_1.2 35.7 TRUE dec
Figure 20: Table of the 6th cluster content


Cluster 68 - 29 transcripts (~ 25% < 3.03 μg/L)

Driver GO terms : muscle contraction

KEGG pathways : Motor proteins

Wikipathways :

Figure 21: DR curves for the 7th cluster
Figure 22: BMDplot for the 7th cluster
id BMD.zSD TF trend
atp2a1_1.1 42.98 FALSE inc
BX936363.1 33.56 FALSE dec
cald1a 4.63 FALSE dec
cx39.9 27.78 FALSE inc
dctn1a_1.2 35.74 FALSE dec
dctn4_1.3 4.08 FALSE bell
dynll2b 3.69 FALSE inc
erp44 3.03 FALSE dec
htr1d 2.67 FALSE inc
kif1b_1.1 5.11 FALSE dec
kifc1_1.2 26.20 FALSE inc
kifc3_1.5 45.08 FALSE dec
myhz1.1_2.1 2.79 FALSE inc
myhz1.2_1.2 1.92 FALSE inc
myhz1.3 4.89 FALSE inc
mylpfa_1.2 4.62 FALSE inc
myo1b_1.3 2.90 FALSE dec
MYO1D 4.14 FALSE dec
rock2a_1.2 3.57 FALSE U
scn4ba 34.66 FALSE dec
tnnc2 6.22 FALSE inc
tnni2a.4_1.2 24.82 FALSE inc
tnni4b.2 29.69 FALSE inc
tnnt1_1.2 0.16 FALSE bell
tnnt1_1.3 51.02 FALSE inc
tnnt3b_1.4 3.91 FALSE inc
tnnt3b_1.5 1.94 FALSE inc
tpma_1.3 49.56 FALSE inc
tubb4b_1.2 2.47 FALSE dec
Figure 23: Table of the 7th cluster content


Cluster 56 - 29 transcripts (~ 25% < 3.08 μg/L)

Driver GO terms : carbohydrate metabolic process

KEGG pathways : N-Glycan biosynthesis, Various types of N-glycan biosynthesis

Wikipathways :

Figure 24: DR curves for the 8th cluster
Figure 25: BMDplot for the 8th cluster
id BMD.zSD TF trend
agla_1.1 3.0 FALSE dec
b4galt6 38.5 FALSE dec
CABZ01079192.1 1.7 FALSE dec
chia.1 0.3 FALSE U
CR759923.1_1.4 2.2 FALSE inc
CR774178.2 5.1 FALSE dec
eno1a_1.2 5.3 FALSE inc
ganab 34.4 FALSE dec
GANAB_1.2 2.6 FALSE dec
gcgra_2.1 3.5 FALSE dec
hexa_1.1 30.8 FALSE dec
hexb_1.3 39.7 FALSE dec
hkdc1_2.1 3.1 FALSE dec
insrb 35.5 FALSE dec
kctd10 4.7 FALSE U
lancl1 1.9 FALSE inc
man1a1 36.4 FALSE dec
man1b1b 36.7 FALSE dec
MAN1C1_1.2 29.0 FALSE dec
man2a1 3.1 FALSE dec
mgat5 35.6 FALSE dec
myorg 3.3 FALSE dec
pdk1 32.3 FALSE dec
pgk1 36.4 FALSE inc
phkb_1.4 4.6 FALSE inc
phkg1b_1.2 42.1 FALSE inc
phkg2 4.6 FALSE U
srd5a3 25.2 FALSE inc
st6galnac4 23.1 FALSE dec
Figure 26: Table of the 8th cluster content


Cluster 64 - 36 transcripts (~ 25% < 3.23 μg/L)

Driver GO terms : protein glycosylation

KEGG pathways : N-Glycan biosynthesis, Protein processing in endoplasmic reticulum, Various types of N-glycan biosynthesis

Wikipathways :

Figure 27: DR curves for the 9th cluster
Figure 28: BMDplot for the 9th cluster
id BMD.zSD TF trend
alg11_1.2 23.4 FALSE dec
atf6 30.3 TRUE dec
calr3b 4.1 FALSE dec
canx 4.1 FALSE dec
crppa 19.0 FALSE inc
dnajb11 2.9 FALSE dec
dnajc1 33.8 TRUE inc
dnajc5aa 39.5 FALSE dec
eif2s1b 34.6 FALSE inc
ext1c_1.1 1.5 FALSE inc
ganab 34.4 FALSE dec
GANAB_1.2 2.6 FALSE dec
hexb_1.3 39.7 FALSE dec
hsp70l 68.6 FALSE inc
hspa1b 20.5 TRUE inc
march6_1.2 39.1 FALSE dec
mgat5 35.6 FALSE dec
mlec 2.9 FALSE dec
ogt.1_2.1 2.9 FALSE inc
pdia3_1.2 3.0 FALSE dec
pdia6 5.5 FALSE dec
pomgnt1_1.2 33.9 FALSE inc
pomgnt1_2.1 36.1 FALSE inc
pomt2 29.4 FALSE inc
rnf185_1.2 28.7 FALSE inc
RNF5 31.9 FALSE dec
rpn1_1.2 3.3 FALSE dec
rpn2_1.1 4.0 FALSE dec
sec61b_1.2 3.2 FALSE dec
selenos 3.2 FALSE U
srd5a3 25.2 FALSE inc
ssr2_1.2 2.8 FALSE dec
st3gal7 2.8 FALSE dec
st6galnac4 23.1 FALSE dec
stt3b 3.3 FALSE dec
xbp1_1.2 48.4 TRUE inc
Figure 29: Table of the 9th cluster content


Cluster 29 - 30 transcripts (~ 25% < 3.31 μg/L)

Driver GO terms : RNA splicing, via transesterification reactions

KEGG pathways : Spliceosome

Wikipathways :

Figure 30: DR curves for the 10th cluster
Figure 31: BMDplot for the 10th cluster
id BMD.zSD TF trend
gemin2 32.3 FALSE inc
gemin8_2.1 42.5 FALSE dec
hnrnpa1b_1.2 2.2 FALSE inc
hnrnpk_1.3 59.0 FALSE dec
hnrnpm_1.3 2.0 FALSE bell
hnrnpm_1.4 33.9 FALSE dec
hnrnpua 45.0 FALSE dec
hsp70l 68.6 FALSE inc
hspa1b 20.5 TRUE inc
LSM2_1.4 3.2 FALSE dec
lsm5_1.2 4.4 FALSE inc
pcbp4_1.1 2.5 FALSE dec
puf60a_1.3 3.5 TRUE inc
rbm15_2.1 35.7 TRUE dec
rbm4.2 1.8 FALSE bell
rbm4.3 24.1 FALSE dec
rbm5_1.2 36.6 FALSE dec
rp9_1.3 3.2 FALSE inc
sf1_1.2 41.2 FALSE dec
sf3b6 32.7 FALSE inc
snrnp25 29.2 FALSE inc
snrnp27 42.6 FALSE inc
snrpd2 57.0 FALSE inc
snrpg 40.8 FALSE inc
snu13b 40.3 FALSE inc
srsf5b_1.1 3.2 FALSE bell
taf15_1.1 1.4 FALSE dec
thoc1 32.0 FALSE inc
wbp11_1.1 33.1 FALSE dec
zgc:55733_1.2 33.6 TRUE inc
Figure 32: Table of the 10th cluster content


Cluster 34 - 13 transcripts (~ 25% < 3.34 μg/L)

Driver GO terms : purine-containing compound biosynthetic process

KEGG pathways : Nucleotide metabolism, Purine metabolism

Wikipathways :

Figure 33: DR curves for the 11th cluster
Figure 34: BMDplot for the 11th cluster
id BMD.zSD TF trend
acsl1b 2.2 FALSE dec
adka_1.2 3.3 FALSE dec
adkb_1.2 54.6 FALSE inc
ak1 6.3 FALSE inc
ampd3b 3.0 FALSE dec
atp5f1c 24.5 FALSE inc
impdh1b_1.2 33.6 FALSE dec
mt-atp6 3.5 FALSE inc
mt-atp8 34.3 FALSE inc
paics_1.1 3.1 FALSE dec
pde3b 33.0 FALSE dec
si:ch73-265d7.2 5.1 FALSE inc
zgc:110540 25.4 FALSE inc
Figure 35: Table of the 11th cluster content


Cluster 66 - 4 transcripts (~ 25% < 2.06 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 36: DR curves for the 12th cluster
Figure 37: BMDplot for the 12th cluster
id BMD.zSD TF trend
atg3 2.2 FALSE U
pi4kaa 42.3 FALSE dec
pik3c3_1.2 3.9 FALSE inc
rab5ab 1.7 FALSE dec
Figure 38: Table of the 12th cluster content


Cluster 55 - 52 transcripts (~ 25% < 3.53 μg/L)

Driver GO terms :

KEGG pathways : Regulation of actin cytoskeleton, Salmonella infection, Tight junction

Wikipathways :

Figure 39: DR curves for the 13th cluster
Figure 40: BMDplot for the 13th cluster
id BMD.zSD TF trend
abi1b_1.2 49.3 FALSE dec
acbd3 27.1 FALSE dec
ACBD3 2.6 FALSE dec
actb2_1.2 3.8 TRUE dec
actr2a 4.6 FALSE dec
actr2b 5.2 FALSE dec
afdna_1.1 45.2 FALSE dec
akt3a_1.2 37.9 FALSE dec
arf2a_1.1 2.6 FALSE U
arf2a_1.2 3.0 FALSE dec
arhgap35a 34.2 TRUE dec
braf_1.2 2.8 FALSE bell
cldn11a 46.6 FALSE inc
cldna 2.9 FALSE dec
cldnk 3.4 FALSE inc
dctn1a_1.2 35.7 FALSE dec
dctn4_1.3 4.1 FALSE bell
dlg1l_1.3 32.7 FALSE dec
dlg1l_1.4 4.1 FALSE dec
dnm2a_1.2 2.2 FALSE dec
dynll2b 3.7 FALSE inc
enah_1.2 5.5 FALSE U
enah_1.3 38.4 FALSE inc
ezra 3.1 FALSE dec
ezrb_1.3 4.2 TRUE dec
fgd1_1.4 39.3 FALSE dec
fyco1a_1.2 3.9 FALSE dec
hdr_1.2 2.0 FALSE dec
itgb8 49.1 FALSE dec
jam2a_1.3 38.9 FALSE inc
kpna1 2.8 FALSE bell
kpna3 2.5 FALSE dec
kras_1.2 37.2 FALSE dec
llgl2_1.3 3.9 FALSE dec
map3k1 5.2 FALSE dec
mapk14b_1.3 57.9 FALSE dec
myh9b_1.2 3.6 FALSE dec
mylkb_1.2 2.9 FALSE dec
pak4 4.1 FALSE dec
pak6a 43.7 FALSE dec
pard6b 7.5 FALSE dec
ppp1r12a 31.7 FALSE dec
ppp2r2bb_1.3 4.7 FALSE bell
ppp2r2d 21.2 FALSE dec
rab5aa 36.9 FALSE dec
rock2a_1.2 3.6 FALSE U
scrib_1.3 38.3 FALSE dec
tcf7l1a_1.2 34.9 TRUE dec
tcf7l1b_1.1 5.1 TRUE dec
tjap1 32.4 FALSE dec
tubb4b_1.2 2.5 FALSE dec
zgc:112437 41.2 FALSE inc
Figure 41: Table of the 13th cluster content


Cluster 32 - 45 transcripts (~ 25% < 3.64 μg/L)

Driver GO terms : RNA splicing

KEGG pathways : Spliceosome

Wikipathways :

Figure 42: DR curves for the 14th cluster
Figure 43: BMDplot for the 14th cluster
id BMD.zSD TF trend
clk2a_1.1 7.0 FALSE dec
ddx5_1.1 2.5 TRUE dec
ddx5_1.4 4.0 TRUE inc
gemin2 32.3 FALSE inc
gemin8_2.1 42.5 FALSE dec
hmga1a_1.1 3.6 TRUE dec
hmga1a_1.2 2.8 TRUE dec
hmga1a_1.3 4.9 TRUE inc
hnrnpa1b_1.2 2.2 FALSE inc
hnrnpk_1.3 59.0 FALSE dec
hnrnpm_1.3 2.0 FALSE bell
hnrnpm_1.4 33.9 FALSE dec
hnrnpua 45.0 FALSE dec
hsp70l 68.6 FALSE inc
hspa1b 20.5 TRUE inc
pcbp4_1.1 2.5 FALSE dec
ppil1 34.7 FALSE inc
prpf18_1.2 45.1 FALSE dec
ptbp3 20.6 FALSE dec
puf60a_1.3 3.5 TRUE inc
qkia_1.2 32.5 FALSE dec
rbfox1l_1.1 35.5 FALSE inc
rbfox1l_2.1 31.9 FALSE inc
rbm15_2.1 35.7 TRUE dec
rbm4.2 1.8 FALSE bell
rbm4.3 24.1 FALSE dec
rbm5_1.2 36.6 FALSE dec
rp9_1.3 3.2 FALSE inc
rtcb_1.2 3.9 FALSE U
sf1_1.2 41.2 FALSE dec
si:dkey-67c22.2_1.2 27.8 FALSE dec
slu7_1.2 4.0 FALSE dec
snrnp25 29.2 FALSE inc
snrnp27 42.6 FALSE inc
snu13b 40.3 FALSE inc
srsf3b_1.1 52.5 FALSE dec
srsf5b_1.1 3.2 FALSE bell
taf15_1.1 1.4 FALSE dec
thoc1 32.0 FALSE inc
thrap3b_1.4 46.3 FALSE dec
thrap3b_1.5 35.7 FALSE dec
tsen2 3.3 FALSE inc
tssc4_1.2 4.8 FALSE inc
wbp11_1.1 33.1 FALSE dec
zgc:55733_1.2 33.6 TRUE inc
Figure 44: Table of the 14th cluster content


Cluster 41 - 13 transcripts (~ 25% < 3.66 μg/L)

Driver GO terms :

KEGG pathways : Vascular smooth muscle contraction

Wikipathways :

Figure 45: DR curves for the 15th cluster
Figure 46: BMDplot for the 15th cluster
id BMD.zSD TF trend
adma 38.2 FALSE inc
braf_1.2 2.8 FALSE bell
cald1b_1.2 23.7 FALSE dec
foxo3b 39.2 TRUE dec
lsp1a 4.3 FALSE dec
mapk3 24.9 FALSE dec
mylkb_1.2 2.9 FALSE dec
ppp1r12a 31.7 FALSE dec
proca1 3.7 FALSE inc
rock2a_1.2 3.6 FALSE U
si:ch73-265d7.2 5.1 FALSE inc
stmn1a_1.2 33.9 FALSE inc
stmn1a_1.3 21.2 FALSE inc
Figure 47: Table of the 15th cluster content


Cluster 33 - 42 transcripts (~ 25% < 3.68 μg/L)

Driver GO terms : canonical NF-kappaB signal transduction

KEGG pathways : Apoptosis, C-type lectin receptor signaling pathway, MAPK signaling pathway

Wikipathways :

Figure 48: DR curves for the 16th cluster
Figure 49: BMDplot for the 16th cluster
id BMD.zSD TF trend
akt3a_1.2 37.91 FALSE dec
arf2b_1.2 3.69 FALSE dec
birc5a 25.59 TRUE inc
braf_1.2 2.79 FALSE bell
cacng1a 30.61 FALSE inc
cts12 52.43 FALSE dec
ctsh 33.75 FALSE inc
ctss2.2 58.70 FALSE inc
cylda_1.2 2.29 FALSE inc
eif2s1b 34.59 FALSE inc
hdr_1.2 2.03 FALSE dec
hsp70l 68.64 FALSE inc
hspa1b 20.47 TRUE inc
ikbkg_1.1 2.06 TRUE dec
ikbkg_1.2 2.42 TRUE bell
insrb 35.55 FALSE dec
irf2a_1.2 3.10 TRUE inc
irf7_1.2 23.10 TRUE inc
jund 42.72 TRUE dec
kras_1.2 37.23 FALSE dec
ksr1b_1.4 37.30 FALSE inc
lamtor3 33.76 FALSE inc
lmnb2 20.38 FALSE dec
map3k1 5.24 FALSE dec
map3k14a 35.23 FALSE inc
map4k6 0.79 FALSE bell
mapk14b_1.3 57.92 FALSE dec
mcl1a 24.25 FALSE inc
mef2cb_1.5 41.30 TRUE dec
mtdha_1.2 1.63 FALSE dec
n4bp1 31.11 FALSE dec
plcg2_1.2 4.02 FALSE dec
ppm1ba 32.96 FALSE dec
ppm1bb 28.92 FALSE dec
ptpn11a_1.2 3.08 FALSE dec
ptpn13_1.5 0.84 FALSE dec
rap1b 3.67 FALSE dec
rps6ka2 4.53 FALSE bell
s100b 27.44 FALSE inc
scaf11_1.1 37.16 FALSE dec
taok1a_1.2 39.92 FALSE dec
taok2b 39.79 FALSE dec
Figure 50: Table of the 16th cluster content


Cluster 57 - 24 transcripts (~ 25% < 3.69 μg/L)

Driver GO terms : COPII-coated vesicle budding

KEGG pathways : Protein processing in endoplasmic reticulum

Wikipathways :

Figure 51: DR curves for the 17th cluster
Figure 52: BMDplot for the 17th cluster
id BMD.zSD TF trend
atf6 30.3 TRUE dec
calr3b 4.1 FALSE dec
canx 4.1 FALSE dec
dnajb11 2.9 FALSE dec
dnajc1 33.8 TRUE inc
dnajc5aa 39.5 FALSE dec
eif2s1b 34.6 FALSE inc
ganab 34.4 FALSE dec
GANAB_1.2 2.6 FALSE dec
hsp70l 68.6 FALSE inc
hspa1b 20.5 TRUE inc
march6_1.2 39.1 FALSE dec
pdia3_1.2 3.0 FALSE dec
pdia6 5.5 FALSE dec
rnf185_1.2 28.7 FALSE inc
RNF5 31.9 FALSE dec
sar1ab 41.5 FALSE inc
sar1b 3.8 FALSE dec
sec23a 5.0 FALSE dec
sec31b_1.2 37.0 FALSE dec
sec61b_1.2 3.2 FALSE dec
selenos 3.2 FALSE U
ssr2_1.2 2.8 FALSE dec
xbp1_1.2 48.4 TRUE inc
Figure 53: Table of the 17th cluster content


Cluster 13 - 49 transcripts (~ 25% < 3.75 μg/L)

Driver GO terms : protein folding

KEGG pathways : Protein processing in endoplasmic reticulum

Wikipathways :

Figure 54: DR curves for the 18th cluster
Figure 55: BMDplot for the 18th cluster
id BMD.zSD TF trend
ahsa1a_1.3 4.51 FALSE inc
apaf1_1.2 0.42 FALSE U
atf6 30.28 TRUE dec
CABZ01080568.1 17.80 FALSE inc
calr3b 4.13 FALSE dec
canx 4.14 FALSE dec
cct2_1.1 6.77 FALSE inc
cct3 36.08 FALSE inc
cct4 36.43 FALSE inc
cct5 38.40 FALSE inc
cct6a_1.3 37.45 FALSE inc
cct7 49.62 FALSE inc
cct8_1.2 3.13 FALSE inc
dnajb11 2.88 FALSE dec
dnajc1 33.78 TRUE inc
dnajc18 3.75 FALSE inc
dnajc5aa 39.49 FALSE dec
eif2s1b 34.59 FALSE inc
erp44 3.03 FALSE dec
ganab 34.36 FALSE dec
GANAB_1.2 2.64 FALSE dec
hsp70.1_1.2 52.68 FALSE inc
hsp70l 68.64 FALSE inc
hsp90aa1.1 17.69 FALSE inc
hspa1b 20.47 TRUE inc
hspa4b_2.1 57.99 FALSE inc
hspa8_2.1 51.24 FALSE inc
hsph1 4.29 FALSE inc
march6_1.2 39.13 FALSE dec
p4hb_1.1 2.25 FALSE dec
pdia3_1.2 2.97 FALSE dec
pdia6 5.55 FALSE dec
pfdn2 32.09 FALSE inc
pfdn4 41.34 FALSE inc
pfdn5_2.1 40.91 FALSE inc
pfdn5_3.1 28.01 TRUE inc
ppiaa 27.20 FALSE inc
ppid_1.2 25.06 TRUE inc
rnf185_1.2 28.70 FALSE inc
RNF5 31.93 FALSE dec
rpap3 37.41 FALSE inc
sec61b_1.2 3.23 FALSE dec
selenos 3.23 FALSE U
si:ch211-131k2.3 18.50 FALSE inc
ssr2_1.2 2.82 FALSE dec
st13 2.78 FALSE dec
tor1_1.2 2.53 FALSE dec
wdr83os_1.1 25.27 FALSE inc
xbp1_1.2 48.44 TRUE inc
Figure 56: Table of the 18th cluster content


Cluster 24 - 13 transcripts (~ 25% < 4.08 μg/L)

Driver GO terms : Notch signaling pathway

KEGG pathways : Notch signaling pathway

Wikipathways :

Figure 57: DR curves for the 19th cluster
Figure 58: BMDplot for the 19th cluster
id BMD.zSD TF trend
chsy1 43.3 FALSE dec
dlb 4.1 FALSE inc
dtx4a 47.1 FALSE dec
egfl6_1.1 39.9 FALSE inc
gmds_1.1 5.8 FALSE dec
gmds_1.3 3.1 FALSE dec
lfng_1.2 24.1 FALSE inc
notch1a_1.2 2.3 TRUE inc
notch1b_1.3 48.6 FALSE dec
nr2f2_1.2 42.5 TRUE dec
plvapb 57.5 FALSE inc
psen2 1.9 FALSE dec
tcima 31.7 FALSE inc
Figure 59: Table of the 19th cluster content


Cluster 30 - 49 transcripts (~ 25% < 4.09 μg/L)

Driver GO terms : mRNA processing

KEGG pathways : mRNA surveillance pathway

Wikipathways : mRNA processing

Figure 60: DR curves for the 20th cluster
Figure 61: BMDplot for the 20th cluster
id BMD.zSD TF trend
celf2_1.2 32.7 FALSE dec
celf2_1.4 27.6 FALSE dec
clk2a_1.1 7.0 FALSE dec
cpsf3 57.2 FALSE inc
cpsf6_1.2 2.1 FALSE dec
cstf2_1.2 3.7 FALSE inc
ern1 60.3 TRUE dec
FNDC10 4.5 FALSE inc
gemin2 32.3 FALSE inc
gemin8_2.1 42.5 FALSE dec
hnrnpa1b_1.2 2.2 FALSE inc
hnrnpaba_1.3 7.9 FALSE dec
hnrnpk_1.3 59.0 FALSE dec
hnrnpm_1.3 2.0 FALSE bell
hnrnpm_1.4 33.9 FALSE dec
hnrnpua 45.0 FALSE dec
msi2b_1.6 4.1 FALSE inc
msi2b_1.8 38.4 FALSE dec
pabpn1_1.1 4.6 FALSE inc
pabpn1_1.3 28.7 FALSE dec
papolg 2.3 FALSE bell
pcbp4_1.1 2.5 FALSE dec
ppp2r2bb_1.3 4.7 FALSE bell
ppp2r2d 21.2 FALSE dec
ppp2r3c 26.2 FALSE inc
ptbp3 20.6 FALSE dec
puf60a_1.3 3.5 TRUE inc
qkia_1.2 32.5 FALSE dec
rbm15_2.1 35.7 TRUE dec
rbm26_1.2 32.0 FALSE dec
rbm27 33.7 FALSE dec
rbm39a_1.4 1.4 TRUE dec
rbm39a_1.5 3.9 TRUE inc
rbm39b_1.1 5.1 FALSE inc
rbm4.2 1.8 FALSE bell
rbm4.3 24.1 FALSE dec
rbm5_1.2 36.6 FALSE dec
sf1_1.2 41.2 FALSE dec
smn1_1.2 37.1 FALSE inc
smndc1_1.1 51.3 FALSE inc
smx5 29.4 FALSE inc
snrnp25 29.2 FALSE inc
snu13b 40.3 FALSE inc
srsf5b_1.1 3.2 FALSE bell
taf15_1.1 1.4 FALSE dec
thoc7 32.7 FALSE inc
tssc4_1.2 4.8 FALSE inc
xrn2_1.2 28.1 TRUE dec
zc3h6 44.1 FALSE dec
Figure 62: Table of the 20th cluster content


Cluster 70 - 4 transcripts (~ 25% < 4.13 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 63: DR curves for the 21st cluster
Figure 64: BMDplot for the 21st cluster
id BMD.zSD TF trend
eif4a2_1.2 4.2 FALSE inc
eif4ba_1.4 41.6 FALSE dec
eif4bb_1.3 4.0 FALSE dec
eif4g1a_1.3 4.6 FALSE U
Figure 65: Table of the 21st cluster content


Cluster 16 - 37 transcripts (~ 25% < 4.18 μg/L)

Driver GO terms : chromatin organization

KEGG pathways : ATP-dependent chromatin remodeling

Wikipathways :

Figure 66: DR curves for the 22nd cluster
Figure 67: BMDplot for the 22nd cluster
id BMD.zSD TF trend
asf1ba 41.2 FALSE inc
baz1b_1.2 52.9 TRUE dec
brd1b 42.2 FALSE dec
brd8_1.3 6.9 FALSE dec
brd8_1.4 4.2 FALSE inc
brpf1_1.1 42.5 FALSE dec
cbx1b_1.3 3.4 FALSE inc
cbx3b 3.1 FALSE inc
cbx5_1.2 45.2 TRUE inc
chd7_1.3 54.7 TRUE dec
chrac1_1.2 25.0 TRUE inc
dek_1.2 36.7 TRUE inc
ep400_1.2 3.4 TRUE inc
h1-10 41.0 FALSE inc
hdac4_1.2 34.3 TRUE dec
hdac5_1.2 35.1 TRUE dec
hnrnpua 45.0 FALSE dec
ing4 3.1 TRUE inc
kat6a 42.2 TRUE dec
l3mbtl2_1.3 34.9 TRUE inc
lmnb2 20.4 FALSE dec
mbd1a_1.3 33.8 FALSE dec
meaf6_1.2 2.6 TRUE inc
morf4l1 31.8 TRUE inc
nap1l1 3.2 FALSE dec
nap1l4a_2.2 53.5 FALSE inc
npm3_1.2 58.9 TRUE inc
nsd3_1.3 45.4 TRUE dec
seta 38.7 FALSE inc
setb_1.1 2.3 TRUE inc
si:ch211-103n10.5 24.5 FALSE dec
smarcb1b_1.3 2.9 FALSE inc
smyd1b_1.2 34.9 TRUE inc
smyd4 37.1 FALSE inc
ttn.2_1.4 2.6 FALSE inc
waca 40.0 TRUE dec
yeats4 48.8 TRUE inc
Figure 68: Table of the 22nd cluster content


Cluster 12 - 47 transcripts (~ 25% < 4.19 μg/L)

Driver GO terms : generation of precursor metabolites and energy

KEGG pathways : Cardiac muscle contraction, Oxidative phosphorylation, Arginine and proline metabolism

Wikipathways : Electron transport chain

Figure 69: DR curves for the 23rd cluster
Figure 70: BMDplot for the 23rd cluster
id BMD.zSD TF trend
agla_1.1 3.0 FALSE dec
agmat 2.8 FALSE dec
aldh2.1 57.4 FALSE inc
aldh3a2b 3.0 FALSE dec
arg2 24.5 FALSE inc
atp1a3a 58.6 FALSE dec
atp2a1_1.1 43.0 FALSE inc
atp2a2b 3.3 FALSE dec
atp2a3_1.3 2.8 FALSE dec
atp5f1c 24.5 FALSE inc
cacng1a 30.6 FALSE inc
ckmb 30.6 FALSE inc
coa6 4.6 FALSE inc
cox11_1.2 32.8 FALSE inc
eno1a_1.2 5.3 FALSE inc
hacl1_1.2 3.5 FALSE U
higd1a 41.2 FALSE inc
hkdc1_2.1 3.1 FALSE dec
insrb 35.5 FALSE dec
mao 2.4 FALSE dec
mt-atp6 3.5 FALSE inc
mt-atp8 34.3 FALSE inc
mt-co1 3.8 FALSE inc
mt-co2 5.5 FALSE inc
mt-co3 3.6 FALSE inc
mt-nd2 5.3 FALSE inc
oat_1.2 35.2 FALSE inc
odc1_1.3 35.8 FALSE inc
oxct1a_1.2 3.2 FALSE inc
pgk1 36.4 FALSE inc
phkb_1.4 4.6 FALSE inc
phkg1b_1.2 42.1 FALSE inc
phkg2 4.6 FALSE U
ppa1b 29.1 FALSE inc
pycr1b 31.6 FALSE inc
sat1a.2_1.2 37.4 FALSE inc
sat2b 26.9 FALSE inc
sco1_1.1 44.6 FALSE inc
sdhb 40.8 FALSE inc
sdhc_1.2 29.1 FALSE inc
si:ch211-139a5.9_1.1 29.7 FALSE inc
slc25a55b 39.0 FALSE dec
slc8a2b 47.0 FALSE dec
smox_1.3 6.2 FALSE inc
surf1 35.7 FALSE inc
trdn_1.4 57.1 FALSE dec
ucp2 53.2 FALSE inc
Figure 71: Table of the 23rd cluster content


Cluster 15 - 37 transcripts (~ 25% < 4.2 μg/L)

Driver GO terms : sphingolipid metabolic process, transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG pathways : Sphingolipid metabolism, TGF-beta signaling pathway

Wikipathways :

Figure 72: DR curves for the 24th cluster
Figure 73: BMDplot for the 24th cluster
id BMD.zSD TF trend
acvr1ba 39.1 FALSE dec
acvr1bb_1.2 27.0 FALSE dec
acvr2ba_1.3 25.1 FALSE dec
acvr2bb 39.5 FALSE dec
asah2 1.3 FALSE dec
b4galt6 38.5 FALSE dec
bmpr2a 46.2 FALSE dec
bmpr2b 39.1 FALSE dec
cers2a_1.2 25.8 FALSE dec
cers3a_1.2 1.7 FALSE dec
cers5 2.6 FALSE dec
flcn_1.2 3.6 FALSE inc
hexb_1.3 39.7 FALSE dec
hjv_1.2 32.3 FALSE inc
kdsr_1.2 2.4 FALSE dec
lats1_1.2 40.7 FALSE dec
ldlrad4a_1.2 32.4 FALSE dec
ldlrad4b 21.8 FALSE dec
lemd3 35.5 FALSE dec
nomo 33.6 FALSE dec
plpp3 5.3 FALSE dec
ppm1bb 28.9 FALSE dec
rbm14a_2.1 4.2 FALSE dec
sgpl1_1.1 2.6 FALSE dec
si:dkey-222b8.1_2.1 30.3 TRUE dec
skia 23.1 TRUE dec
skib 2.9 FALSE bell
skila_1.2 44.8 TRUE dec
skila_1.3 44.0 TRUE dec
skila_1.4 47.4 TRUE dec
smad2_1.2 33.1 TRUE dec
smad2_1.3 33.5 TRUE dec
smurf2 28.0 TRUE dec
SPHK1 36.0 FALSE dec
sphk2 3.6 FALSE dec
st6galnac4 23.1 FALSE dec
ugt8_2.1 4.1 FALSE dec
Figure 74: Table of the 24th cluster content


Cluster 26 - 32 transcripts (~ 25% < 4.36 μg/L)

Driver GO terms : carboxylic acid metabolic process

KEGG pathways : Biosynthesis of amino acids, Cysteine and methionine metabolism

Wikipathways :

Figure 75: DR curves for the 25th cluster
Figure 76: BMDplot for the 25th cluster
id BMD.zSD TF trend
abcd1_1.2 4.7 FALSE dec
acox3 3.1 FALSE dec
acsl1b 2.2 FALSE dec
adi1 28.8 FALSE inc
aldh1l1_2.1 2.9 FALSE dec
alox12 3.4 FALSE dec
apip 37.3 FALSE inc
asdurf_1.2 40.5 FALSE inc
aspg_1.3 14.0 FALSE inc
azin1b 53.0 FALSE inc
cad_1.2 27.1 FALSE inc
cpt1aa_1.2 3.0 FALSE dec
cth 32.7 TRUE inc
eno1a_1.2 5.3 FALSE inc
gclm 2.9 FALSE dec
ggctb 35.5 FALSE inc
gldc 25.7 FALSE inc
glulb_1.1 36.3 FALSE inc
glulb_1.2 30.2 FALSE inc
got1_1.1 5.9 FALSE dec
gpam 30.8 FALSE dec
hkdc1_2.1 3.1 FALSE dec
HPDL 28.3 FALSE inc
insrb 35.5 FALSE dec
ldhba 31.9 FALSE inc
oat_1.2 35.2 FALSE inc
pgk1 36.4 FALSE inc
phgdh 17.9 FALSE inc
psat1 9.3 FALSE inc
pycr1b 31.6 FALSE inc
scd 24.0 FALSE inc
unknown.101 2.2 FALSE dec
Figure 77: Table of the 25th cluster content


Cluster 8 - 81 transcripts (~ 25% < 4.39 μg/L)

Driver GO terms : canonical Wnt signaling pathway, embryonic organ morphogenesis

KEGG pathways : Adherens junction, Melanogenesis, Mitophagy - animal, mTOR signaling pathway, Ribosome biogenesis in eukaryotes, Wnt signaling pathway

Wikipathways : Non canonical Wnt pathway, Wnt Signaling Pathway, Wnt Signaling Pathway and Pluripotency

Figure 78: DR curves for the 26th cluster
Figure 79: BMDplot for the 26th cluster
id BMD.zSD TF trend
acp1_1.1 32.6 FALSE inc
afdna_1.1 45.2 FALSE dec
ahsa1a_1.3 4.5 FALSE inc
akt3a_1.2 37.9 FALSE dec
atg9a_1.4 43.4 FALSE inc
bcl9_1.2 45.0 TRUE dec
braf_1.2 2.8 FALSE bell
cacybp 27.0 FALSE inc
cdh1_1.2 4.4 FALSE dec
chd7_1.3 54.7 TRUE dec
chsy1 43.3 FALSE dec
clul1_2.1 39.8 FALSE dec
csnk1g2a_1.2 30.3 FALSE dec
csnk2a2a 4.6 FALSE inc
csnk2a4 1.0 FALSE U
ctnnb1_1.1 32.8 TRUE dec
ctnnd1_1.2 4.7 TRUE dec
daam1a_1.2 51.7 FALSE dec
depdc5_1.1 3.9 FALSE inc
eif2s1b 34.6 FALSE inc
eif4e2 4.8 FALSE inc
fabp3 38.4 FALSE inc
farp2_1.2 9.1 FALSE U
furina_2.1 2.8 FALSE dec
fzd1 2.6 FALSE U
fzd10 42.4 FALSE inc
grb10a 3.5 FALSE dec
gsk3ba 22.3 TRUE dec
gskip 3.9 FALSE dec
hdac4_1.2 34.3 TRUE dec
insrb 35.5 FALSE dec
irs1 27.5 FALSE dec
kctd10 4.7 FALSE U
kras_1.2 37.2 FALSE dec
lamtor3 33.8 FALSE inc
ldlra_1.1 33.3 FALSE dec
lrp5_1.2 4.4 FALSE dec
mapkap1_1.2 19.0 FALSE dec
mef2cb_1.5 41.3 TRUE dec
meis1b_1.1 4.1 TRUE inc
mon1a 2.0 FALSE dec
nap1l1 3.2 FALSE dec
nmd3 48.1 FALSE inc
ntn1a_1.2 39.4 FALSE dec
pbx4_1.2 23.0 TRUE dec
ppm1ba 33.0 FALSE dec
ppm1bb 28.9 FALSE dec
ppp2r2bb_1.3 4.7 FALSE bell
ptpn11a_1.2 3.1 FALSE dec
pvrl2l 39.2 FALSE dec
pygo2_1.2 36.3 FALSE dec
rab5aa 36.9 FALSE dec
ran 30.5 TRUE inc
rap1b 3.7 FALSE dec
rnf146_1.2 16.9 FALSE dec
rock2a_1.2 3.6 FALSE U
rps6ka2 4.5 FALSE bell
sgk2b_1.2 2.3 FALSE inc
si:ch211-195b13.1_1.2 5.5 FALSE inc
si:ch73-22o12.1 36.6 FALSE dec
si:dkey-1c11.1_1.2 1.7 FALSE inc
si:dkey-222b8.1_2.1 30.3 TRUE dec
skib 2.9 FALSE bell
smoc1 5.2 FALSE dec
smyd4 37.1 FALSE inc
snu13b 40.3 FALSE inc
sox11a 58.3 TRUE dec
spry2 4.2 FALSE inc
taz_1.4 35.9 FALSE inc
tbl1xr1b 4.7 FALSE dec
tcf7l1a_1.2 34.9 TRUE dec
tcf7l1b_1.1 5.1 TRUE dec
tcf7l2_1.10 42.3 TRUE dec
tfap2c_1.2 1.6 TRUE dec
tti1 27.0 FALSE inc
usp8 31.4 FALSE dec
vangl2 36.5 FALSE dec
wnt4b_2.1 1.4 FALSE bell
xrn1 35.5 FALSE dec
xrn2_1.2 28.1 TRUE dec
zgc:86598_1.2 27.0 TRUE inc
Figure 80: Table of the 26th cluster content


Cluster 21 - 36 transcripts (~ 25% < 4.41 μg/L)

Driver GO terms : microtubule-based process

KEGG pathways :

Wikipathways :

Figure 81: DR curves for the 27th cluster
Figure 82: BMDplot for the 27th cluster
id BMD.zSD TF trend
alms1 2.8 FALSE inc
cep192_1.2 40.0 FALSE inc
cep57 3.2 FALSE inc
cfap298 19.0 FALSE inc
ckap5_1.2 8.2 FALSE inc
cpeb2_1.1 3.2 FALSE bell
cpeb3 34.9 FALSE dec
CU929259.1 22.5 FALSE dec
dynll2b 3.7 FALSE inc
fyco1a_1.2 3.9 FALSE dec
gas2l1_1.2 25.8 FALSE dec
gas2l3 41.1 FALSE dec
haus4 30.8 FALSE inc
hnrnpua 45.0 FALSE dec
kif1b_1.1 5.1 FALSE dec
kif2c_1.3 39.0 FALSE inc
kifc1_1.2 26.2 FALSE inc
kifc3_1.5 45.1 FALSE dec
map1ab_1.2 39.8 FALSE dec
map4l_1.4 4.6 FALSE bell
map7d2a_1.1 58.5 FALSE dec
nckap5l 33.5 FALSE dec
nusap1 37.1 FALSE inc
plk1 45.8 FALSE inc
rock2a_1.2 3.6 FALSE U
si:ch73-217b7.1_1.2 35.1 FALSE dec
si:dkey-57a22.11 1.9 FALSE inc
tacc3_1.2 30.5 FALSE inc
tppp2_2.1 42.5 FALSE inc
tubb4b_1.2 2.5 FALSE dec
tubgcp2 35.0 FALSE inc
tubgcp4 3.4 FALSE inc
tubgcp5 6.7 FALSE inc
zgc:158640 32.8 FALSE inc
zgc:86764_1.2 46.1 FALSE inc
zgc:92429 35.7 FALSE inc
Figure 83: Table of the 27th cluster content


Cluster 7 - 13 transcripts (~ 25% < 4.6 μg/L)

Driver GO terms : regulation of transcription elongation by RNA polymerase II

KEGG pathways :

Wikipathways :

Figure 84: DR curves for the 28th cluster
Figure 85: BMDplot for the 28th cluster
id BMD.zSD TF trend
cdc73_1.2 3.9 TRUE U
cdk12_1.3 22.9 FALSE dec
cdk8_2.1 40.9 TRUE dec
ercc8_1.2 4.6 FALSE inc
ints8_1.2 2.7 FALSE inc
med10_1.1 47.1 TRUE inc
med30 4.7 TRUE inc
med31 42.6 TRUE inc
med7_3.1 29.9 FALSE inc
nelfe_1.2 43.9 FALSE inc
polr2a 32.9 TRUE dec
ssrp1b_1.3 2.7 TRUE inc
supt6h 51.6 TRUE dec
Figure 86: Table of the 28th cluster content


Cluster 14 - 61 transcripts (~ 25% < 4.86 μg/L)

Driver GO terms : DNA metabolic process, organic acid metabolic process

KEGG pathways : Base excision repair, DNA replication, 2-Oxocarboxylic acid metabolism, Biosynthesis of amino acids, Carbon metabolism, Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism

Wikipathways : DNA replication, TCA cycle

Figure 87: DR curves for the 29th cluster
Figure 88: BMDplot for the 29th cluster
id BMD.zSD TF trend
abcd1_1.2 4.7 FALSE dec
aco1 3.4 FALSE dec
acox3 3.1 FALSE dec
acsl1b 2.2 FALSE dec
acss2l 27.5 FALSE inc
adi1 28.8 FALSE inc
aldh1l1_2.1 2.9 FALSE dec
alox12 3.4 FALSE dec
asdurf_1.2 40.5 FALSE inc
aspg_1.3 14.0 FALSE inc
azin1b 53.0 FALSE inc
brca2 16.9 TRUE inc
cad_1.2 27.1 FALSE inc
ccdc36 4.5 FALSE inc
cdk2 25.8 TRUE inc
cpt1aa_1.2 3.0 FALSE dec
cs 4.6 FALSE dec
cyp2ad3 33.4 FALSE inc
cyp2ad6 29.1 FALSE inc
dna2 34.7 FALSE inc
dnmt3bb.1_2.1 6.1 FALSE dec
eno1a_1.2 5.3 FALSE inc
fam168a_1.2 36.1 FALSE dec
fan1_1.1 45.8 FALSE inc
fen1 32.4 FALSE inc
gldc 25.7 FALSE inc
glulb_1.1 36.3 FALSE inc
glulb_1.2 30.2 FALSE inc
gpam 30.8 FALSE dec
hkdc1_2.1 3.1 FALSE dec
hltf_1.2 35.4 TRUE inc
hnrnpua 45.0 FALSE dec
HPDL 28.3 FALSE inc
idh2 3.7 FALSE inc
insrb 35.5 FALSE dec
isg20 4.0 FALSE inc
mad2l2 56.6 TRUE inc
mdh1aa_1.2 2.8 FALSE inc
mnd1_1.2 52.5 FALSE inc
nucks1a 39.3 FALSE dec
oat_1.2 35.2 FALSE inc
palb2_1.2 1.7 FALSE inc
pcna 27.9 FALSE inc
pdk1 32.3 FALSE dec
pgk1 36.4 FALSE inc
phgdh 17.9 FALSE inc
pold2_1.2 26.1 FALSE inc
prim1 29.1 FALSE inc
psat1 9.3 FALSE inc
pycr1b 31.6 FALSE inc
rad51d 27.0 FALSE inc
rbbp8_1.2 5.2 FALSE inc
rev1_2.1 3.9 FALSE inc
rnaseh2a_1.2 33.2 FALSE inc
scd 24.0 FALSE inc
sdhb 40.8 FALSE inc
top1_1.4 34.2 FALSE dec
top1l 26.5 TRUE dec
ube2a_1.2 4.9 FALSE inc
ube2al 38.9 FALSE inc
unknown.76 24.1 FALSE inc
Figure 89: Table of the 29th cluster content


Cluster 5 - 43 transcripts (~ 25% < 5.17 μg/L)

Driver GO terms : protein catabolic process

KEGG pathways : Proteasome

Wikipathways :

Figure 90: DR curves for the 30th cluster
Figure 91: BMDplot for the 30th cluster
id BMD.zSD TF trend
akirin2_1.2 38.0 FALSE dec
anapc4_1.2 4.7 FALSE inc
appbp2 40.1 FALSE dec
arih2_1.1 2.7 FALSE dec
azin1b 53.0 FALSE inc
CR788324.2 33.2 FALSE dec
cul2 30.5 FALSE inc
desi1a 5.3 FALSE inc
fbxo33 37.8 FALSE dec
hectd3_1.2 2.7 FALSE dec
kctd10 4.7 FALSE U
kctd5a 25.2 FALSE dec
lgmn_1.2 1.5 FALSE U
oaz2b 45.6 FALSE inc
pomp 37.3 FALSE inc
ppt1_1.2 45.4 FALSE inc
psma3 36.2 FALSE inc
psma4 39.1 FALSE inc
psma5_1.1 33.1 FALSE inc
psma6b_1.2 45.4 FALSE inc
psmb4 47.0 FALSE inc
psmc1a_2.2 42.8 FALSE inc
psmc4_1.2 38.8 FALSE inc
psmd12 51.7 FALSE inc
psmd13 39.2 FALSE inc
psmd14 42.2 FALSE inc
psmd2 5.1 FALSE dec
psmd4a_1.2 47.9 FALSE inc
psme3_1.2 47.1 FALSE inc
psme4b_2.2 1.2 FALSE bell
rnf146_1.2 16.9 FALSE dec
rock2a_1.2 3.6 FALSE U
uba7 1.8 FALSE U
ube2a_1.2 4.9 FALSE inc
ube2al 38.9 FALSE inc
usp14 36.2 FALSE inc
usp24_1.2 35.4 FALSE dec
usp2a_1.4 38.0 FALSE dec
usp2a_1.5 3.8 FALSE inc
usp32 34.3 FALSE dec
usp4 45.4 FALSE dec
usp8 31.4 FALSE dec
vps37c 32.4 FALSE dec
Figure 92: Table of the 30th cluster content


Cluster 45 - 5 transcripts (~ 25% < 5.28 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 93: DR curves for the 31st cluster
Figure 94: BMDplot for the 31st cluster
id BMD.zSD TF trend
oxsr1a 35.0 FALSE dec
sec62 42.1 FALSE dec
sec63 5.3 FALSE dec
strada 2.1 FALSE inc
STRADB 48.4 FALSE dec
Figure 95: Table of the 31st cluster content


Cluster 20 - 38 transcripts (~ 25% < 6.37 μg/L)

Driver GO terms : ubiquitin-dependent protein catabolic process

KEGG pathways : Ubiquitin mediated proteolysis

Wikipathways :

Figure 96: DR curves for the 32nd cluster
Figure 97: BMDplot for the 32nd cluster
id BMD.zSD TF trend
anapc4_1.2 4.7 FALSE inc
anapc5 23.6 FALSE inc
appbp2 40.1 FALSE dec
arih2_1.1 2.7 FALSE dec
cbl 41.4 TRUE dec
cdc34b 31.4 FALSE dec
CR788324.2 33.2 FALSE dec
cul2 30.5 FALSE inc
fbxo33 37.8 FALSE dec
hectd3_1.2 2.7 FALSE dec
kctd10 4.7 FALSE U
kctd5a 25.2 FALSE dec
map3k1 5.2 FALSE dec
nufip2 29.3 FALSE dec
rnf146_1.2 16.9 FALSE dec
sae1 39.0 FALSE inc
trip12_1.2 27.9 FALSE dec
uba1_1.1 45.7 FALSE dec
uba1_1.2 45.5 FALSE dec
uba7 1.8 FALSE U
ube2a_1.2 4.9 FALSE inc
ube2al 38.9 FALSE inc
ube2c_2.1 38.1 FALSE inc
ube2d2_1.3 7.3 FALSE bell
ube2d4 30.6 FALSE dec
ube2ka 37.7 FALSE inc
ube2l3b_1.1 2.4 FALSE U
UBE2M_1.4 35.4 FALSE inc
UBE2M_1.5 30.8 FALSE dec
usp24_1.2 35.4 FALSE dec
usp2a_1.4 38.0 FALSE dec
usp2a_1.5 3.8 FALSE inc
usp32 34.3 FALSE dec
usp4 45.4 FALSE dec
usp48_1.2 37.7 FALSE inc
usp8 31.4 FALSE dec
vps37c 32.4 FALSE dec
wdr26b 6.1 FALSE dec
Figure 98: Table of the 32nd cluster content


Cluster 1 - 162 transcripts (~ 25% < 6.69 μg/L)

Driver GO terms : ribosomal small subunit assembly, translation, embryo development ending in birth or egg hatching, ribonucleoprotein complex biogenesis, DNA geometric change, DNA replication

KEGG pathways : Ribosome, Cell cycle, DNA replication

Wikipathways : Cytoplasmic ribosomal proteins, Cell cycle, DNA replication, G1 to S cell cycle control

Figure 99: DR curves for the 33rd cluster
Figure 100: BMDplot for the 33rd cluster
id BMD.zSD TF trend
aars1_2.2 14.4 FALSE inc
ahsa1a_1.3 4.5 FALSE inc
anapc4_1.2 4.7 FALSE inc
anapc5 23.6 FALSE inc
btf3 27.6 FALSE inc
btf3l4 25.6 FALSE inc
ccnb1_1.2 24.6 FALSE inc
ccne2_1.3 32.5 FALSE inc
cdh1_1.2 4.4 FALSE dec
cdk2 25.8 TRUE inc
cdkn1ca 45.1 FALSE inc
chd7_1.3 54.7 TRUE dec
cnot1_2.1 39.6 FALSE dec
ctc1 4.1 FALSE inc
ddx6 22.0 FALSE dec
dna2 34.7 FALSE inc
dnm2a_1.2 2.2 FALSE dec
drg1 24.8 FALSE inc
drg2 34.2 FALSE inc
edf1 44.6 TRUE inc
eef1a1l1_1.2 29.8 FALSE inc
eef1a1l1_1.3 49.8 FALSE dec
eef1b2_1.1 39.3 FALSE inc
eef1b2_1.2 39.5 FALSE inc
eef1db_1.1 4.1 FALSE inc
eef1db_1.5 32.1 FALSE inc
eif2s1b 34.6 FALSE inc
eif3ba 40.9 FALSE inc
eif3d_1.4 30.9 FALSE inc
eif3ea_1.3 5.4 FALSE inc
eif3f 35.9 FALSE inc
eif3g 28.0 FALSE inc
eif3ha 40.4 FALSE inc
eif3hb_1.2 44.7 FALSE inc
eif3i 23.9 FALSE inc
eif3jb 37.2 FALSE dec
eif3k 44.3 FALSE inc
eif3m 25.8 FALSE inc
eif4e2 4.8 FALSE inc
eif4ea_1.1 45.9 FALSE dec
eif4ebp2 3.4 FALSE dec
eif4enif1_1.3 32.6 FALSE dec
eif5a2_1.2 3.0 FALSE dec
eif5b_1.2 33.2 FALSE dec
eri1_2.1 29.4 FALSE inc
esco2 25.1 FALSE inc
fabp3 38.4 FALSE inc
faub_2.1 3.1 FALSE U
furina_2.1 2.8 FALSE dec
gemin2 32.3 FALSE inc
gemin8_2.1 42.5 FALSE dec
gins2 25.1 FALSE inc
hdac4_1.2 34.3 TRUE dec
hdac5_1.2 35.1 TRUE dec
hmgn7_1.2 35.2 FALSE inc
insrb 35.5 FALSE dec
kcna4 58.2 FALSE dec
kcnc3a_1.1 44.2 FALSE dec
kras_1.2 37.2 FALSE dec
mcm5 43.1 FALSE inc
mcm7_1.2 43.1 FALSE inc
mcm9 38.8 FALSE inc
mcmbp 26.9 FALSE inc
mcts1 27.2 FALSE inc
mdka_1.1 3.3 FALSE inc
mdka_1.2 46.7 FALSE inc
mdka_1.4 32.5 FALSE inc
meis1b_1.1 4.1 TRUE inc
metap2a 40.2 FALSE dec
metap2b 30.4 FALSE dec
mrpl20 29.4 FALSE inc
mrpl22 27.4 FALSE inc
mrpl27 42.3 FALSE inc
msi2b_1.6 4.1 FALSE inc
msi2b_1.8 38.4 FALSE dec
ndc80 20.1 FALSE inc
ntn1a_1.2 39.4 FALSE dec
orc4 28.9 FALSE inc
pa2g4b_1.1 59.1 FALSE inc
paics_1.1 3.1 FALSE dec
pbx4_1.2 23.0 TRUE dec
pdcd5 29.5 FALSE inc
pin4 37.4 FALSE inc
pitpnaa 3.1 FALSE dec
pola2 37.8 FALSE inc
pole2 30.9 FALSE inc
pole4_1.3 2.6 FALSE inc
prim2_1.2 30.3 FALSE inc
puf60a_1.3 3.5 TRUE inc
rack1_1.1 39.6 FALSE inc
rack1_1.2 6.6 FALSE inc
riok3 22.3 FALSE inc
riox1 33.3 FALSE inc
riox2 30.4 FALSE inc
rnaseh2a_1.2 33.2 FALSE inc
rpl10a_1.1 53.4 FALSE inc
rpl11 41.9 FALSE inc
rpl12_2.1 39.4 FALSE inc
rpl13a 39.3 FALSE inc
rpl14 6.9 FALSE inc
rpl15 42.9 FALSE inc
rpl17_1.1 4.6 FALSE inc
rpl19 35.5 FALSE inc
rpl23 43.8 FALSE inc
rpl27 45.8 FALSE inc
rpl28_1.2 2.1 FALSE inc
rpl29 51.0 FALSE inc
rpl3_1.2 7.8 FALSE inc
rpl32_2.1 25.0 FALSE inc
rpl35 8.2 FALSE inc
rpl36a_1.3 46.0 FALSE inc
rpl38 6.8 FALSE inc
rpl39 42.0 FALSE inc
rpl5a 9.0 FALSE inc
rpl7 33.3 FALSE inc
rpl7a_1.1 5.9 FALSE inc
rpl8_1.2 4.6 FALSE U
rpl9_1.1 7.0 FALSE inc
rpl9_1.2 31.1 FALSE inc
rplp0_1.2 6.2 FALSE inc
rplp2 6.0 FALSE inc
rps11 39.4 FALSE inc
rps13_1.1 3.3 FALSE dec
rps13_1.2 5.8 FALSE inc
rps15 5.8 FALSE inc
rps15a 47.0 FALSE inc
rps18_1.2 28.2 FALSE inc
rps2_1.1 42.6 FALSE inc
rps2_1.2 25.0 FALSE inc
rps24_1.1 3.4 FALSE inc
rps26 6.6 FALSE inc
rps27.1 29.3 FALSE inc
rps27.2_1.2 32.1 FALSE inc
rps27l 57.9 FALSE inc
rps29 4.8 FALSE inc
rps3a_1.1 42.5 FALSE inc
rps5 8.7 FALSE inc
rps6 36.0 FALSE inc
rps7 7.9 FALSE inc
rps8a 5.0 FALSE inc
rps9_2.1 2.6 FALSE inc
rpsa_1.2 59.0 FALSE inc
rwdd1 31.5 FALSE inc
sap130b_1.2 28.7 TRUE dec
serbp1b 33.0 FALSE dec
si:ch211-207d6.2 4.3 FALSE dec
si:dkey-151g10.6 3.5 FALSE inc
si:dkey-222b8.1_2.1 30.3 TRUE dec
si:dkey-46g23.1_1.1 40.9 FALSE dec
si:dkey-96n2.1 3.6 FALSE inc
si:dkeyp-110a12.4 3.4 FALSE inc
slc29a1a 40.8 FALSE dec
snu13b 40.3 FALSE inc
srp54 48.8 FALSE inc
srpra 3.4 FALSE dec
tfap2c_1.2 1.6 TRUE dec
tnrc6c1_1.4 59.3 FALSE dec
top1l 26.5 TRUE dec
tpt1_1.1 24.9 FALSE inc
utp6_3.1 39.3 FALSE inc
ywhae2 37.9 FALSE dec
znf622 4.2 TRUE U
Figure 101: Table of the 33rd cluster content


Cluster 19 - 22 transcripts (~ 25% < 9.35 μg/L)

Driver GO terms : translational initiation

KEGG pathways : Herpes simplex virus 1 infection

Wikipathways :

Figure 102: DR curves for the 34th cluster
Figure 103: BMDplot for the 34th cluster
id BMD.zSD TF trend
akt3a_1.2 37.9 FALSE dec
calr3b 4.1 FALSE dec
cdc123_1.2 34.9 FALSE inc
eif2b1_1.2 25.7 FALSE inc
eif2b3_1.2 37.5 FALSE inc
eif2b4_1.2 25.4 FALSE inc
eif2b5 39.4 FALSE inc
eif2s1b 34.6 FALSE inc
eif2s2 40.6 FALSE inc
eif2s3_1.3 29.3 FALSE inc
eif4e2 4.8 FALSE inc
eif4ea_1.1 45.9 FALSE dec
eif4ebp2 3.4 FALSE dec
eif4enif1_1.3 32.6 FALSE dec
irf7_1.2 23.1 TRUE inc
jak2a_1.1 44.0 FALSE dec
pdia3_1.2 3.0 FALSE dec
ptpn11a_1.2 3.1 FALSE dec
pvrl2l 39.2 FALSE dec
si:ch73-22o12.1 36.6 FALSE dec
srsf5b_1.1 3.2 FALSE bell
tapbp.1 35.7 FALSE inc
Figure 104: Table of the 34th cluster content


Cluster 27 - 16 transcripts (~ 25% < 14.02 μg/L)

Driver GO terms : DNA repair

KEGG pathways : Fanconi anemia pathway

Wikipathways :

Figure 105: DR curves for the 35th cluster
Figure 106: BMDplot for the 35th cluster
id BMD.zSD TF trend
brca2 16.9 TRUE inc
cenpn 32.1 FALSE inc
cenps_2.1 34.1 FALSE inc
faap100 36.9 FALSE inc
fam168a_1.2 36.1 FALSE dec
fan1_1.1 45.8 FALSE inc
FO834799.1 5.2 FALSE inc
nucks1a 39.3 FALSE dec
palb2_1.2 1.7 FALSE inc
rad51d 27.0 FALSE inc
rbbp8_1.2 5.2 FALSE inc
ube2a_1.2 4.9 FALSE inc
ube2al 38.9 FALSE inc
ube2t 41.3 FALSE inc
unknown.76 24.1 FALSE inc
usp1_1.2 23.8 FALSE inc
Figure 107: Table of the 35th cluster content


Cluster 3 - 24 transcripts (~ 25% < 14.03 μg/L)

Driver GO terms : tRNA aminoacylation

KEGG pathways : Aminoacyl-tRNA biosynthesis

Wikipathways :

Figure 108: DR curves for the 36th cluster
Figure 109: BMDplot for the 36th cluster
id BMD.zSD TF trend
aars1_1.2 15.3 FALSE inc
aars1_2.2 14.4 FALSE inc
aimp1a 35.7 FALSE inc
aimp1b_1.4 4.1 FALSE inc
aimp2_1.2 38.0 FALSE inc
dars1 17.8 FALSE inc
dtd1 28.8 FALSE inc
eprs1_1.2 15.4 FALSE inc
farsa 16.2 FALSE inc
farsb 12.4 FALSE inc
gars1 39.3 FALSE inc
hars_1.1 24.9 FALSE inc
iars1 23.9 FALSE inc
kars1_1.1 30.6 FALSE inc
lars2_1.2 4.0 FALSE U
LO017852.1 6.5 FALSE inc
mars1_1.1 2.9 FALSE inc
nars1 12.9 FALSE inc
sars1 19.0 FALSE inc
tars1_2.1 38.4 FALSE inc
vars2 31.8 FALSE inc
wars1 18.2 FALSE inc
WARS1 39.5 FALSE inc
yars1_1.2 22.2 FALSE inc
Figure 110: Table of the 36th cluster content


Cluster 69 - 17 transcripts (~ 25% < 17.13 μg/L)

Driver GO terms :

KEGG pathways : Insulin signaling pathway

Wikipathways :

Figure 111: DR curves for the 37th cluster
Figure 112: BMDplot for the 37th cluster
id BMD.zSD TF trend
akt3a_1.2 37.9 FALSE dec
braf_1.2 2.8 FALSE bell
cbl 41.4 TRUE dec
eif4e2 4.8 FALSE inc
gnas_1.2 34.9 FALSE dec
insrb 35.5 FALSE dec
irs1 27.5 FALSE dec
kras_1.2 37.2 FALSE dec
pde3b 33.0 FALSE dec
phkb_1.4 4.6 FALSE inc
phkg1b_1.2 42.1 FALSE inc
phkg2 4.6 FALSE U
ppargc1a 37.8 TRUE dec
ppp1r3cb_1.2 39.4 FALSE inc
prkacaa 31.2 FALSE dec
prkar1ab 31.9 FALSE dec
prkar2aa 17.1 FALSE dec
Figure 113: Table of the 37th cluster content


Cluster 23 - 20 transcripts (~ 25% < 21.79 μg/L)

Driver GO terms : DNA modification, methylation

KEGG pathways : Cysteine and methionine metabolism

Wikipathways :

Figure 114: DR curves for the 38th cluster
Figure 115: BMDplot for the 38th cluster
id BMD.zSD TF trend
adi1 28.8 FALSE inc
apip 37.3 FALSE inc
dnmt1 34.1 TRUE inc
dnmt3aa_1.2 43.7 FALSE dec
dnmt3ab_1.2 23.1 FALSE dec
dnmt3bb.1_2.1 6.1 FALSE dec
dnmt3bb.3_1.2 36.7 FALSE inc
mto1 52.4 FALSE inc
phgdh 17.9 FALSE inc
prmt7_2.1 33.1 FALSE inc
psat1 9.3 FALSE inc
setd4 32.6 FALSE inc
smyd1b_1.2 34.9 TRUE inc
smyd4 37.1 FALSE inc
tet3_1.2 43.3 FALSE dec
tet3_1.3 2.3 FALSE inc
thumpd3_2.1 31.2 FALSE inc
trdmt1 37.8 FALSE inc
trmt6 1.9 FALSE U
vcpkmt_1.2 33.8 FALSE inc
Figure 116: Table of the 38th cluster content


Cluster 42 - 24 transcripts (~ 25% < 22.31 μg/L)

Driver GO terms : DNA metabolic process

KEGG pathways : Base excision repair, DNA replication, Mismatch repair, Nucleotide excision repair

Wikipathways : DNA replication

Figure 117: DR curves for the 39th cluster
Figure 118: BMDplot for the 39th cluster
id BMD.zSD TF trend
brca2 16.9 TRUE inc
ccdc36 4.5 FALSE inc
cdca7a 31.7 FALSE inc
cdk2 25.8 TRUE inc
dna2 34.7 FALSE inc
dnmt3bb.1_2.1 6.1 FALSE dec
fam168a_1.2 36.1 FALSE dec
fan1_1.1 45.8 FALSE inc
hnrnpua 45.0 FALSE dec
mnd1_1.2 52.5 FALSE inc
nucks1a 39.3 FALSE dec
palb2_1.2 1.7 FALSE inc
rad17 32.9 FALSE inc
rad51d 27.0 FALSE inc
rbbp8_1.2 5.2 FALSE inc
rfc2 33.5 FALSE inc
rfc4_1.5 25.0 FALSE inc
rfc5 34.3 FALSE inc
rnaseh2a_1.2 33.2 FALSE inc
top1_1.4 34.2 FALSE dec
top1l 26.5 TRUE dec
ube2a_1.2 4.9 FALSE inc
ube2al 38.9 FALSE inc
unknown.76 24.1 FALSE inc
Figure 119: Table of the 39th cluster content


Cluster 47 - 4 transcripts (~ 25% < 22.88 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 120: DR curves for the 40th cluster
Figure 121: BMDplot for the 40th cluster
id BMD.zSD TF trend
acta1b 28.8 FALSE dec
cttn_1.2 5.2 FALSE dec
scinla 33.2 FALSE inc
shroom3_1.2 55.4 FALSE dec
Figure 122: Table of the 40th cluster content


Cluster 67 - 5 transcripts (~ 25% < 23.12 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 123: DR curves for the 41st cluster
Figure 124: BMDplot for the 41st cluster
id BMD.zSD TF trend
ppp1caa 23.1 FALSE dec
ppp1cbl 36.0 FALSE inc
ppp1r14aa 63.5 FALSE inc
ppp1r7_1.1 43.0 FALSE dec
ppp1r7_1.2 4.2 FALSE inc
Figure 125: Table of the 41st cluster content


Cluster 4 - 80 transcripts (~ 25% < 23.78 μg/L)

Driver GO terms : respiratory electron transport chain, translation

KEGG pathways : Cardiac muscle contraction, Oxidative phosphorylation, Ribosome

Wikipathways : Electron transport chain, Oxidative phosphorylation

Figure 126: DR curves for the 42nd cluster
Figure 127: BMDplot for the 42nd cluster
id BMD.zSD TF trend
aars1_2.2 14.4 FALSE inc
atp1a3a 58.6 FALSE dec
atp2a1_1.1 43.0 FALSE inc
atp2a2b 3.3 FALSE dec
atp2a3_1.3 2.8 FALSE dec
atp5f1c 24.5 FALSE inc
CABZ01102240.1_1.1 4.2 FALSE inc
cacng1a 30.6 FALSE inc
cnot1_2.1 39.6 FALSE dec
cox6b2 35.3 FALSE inc
cox7a2a_1.2 38.4 FALSE inc
ddx6 22.0 FALSE dec
drg1 24.8 FALSE inc
drg2 34.2 FALSE inc
eef1a1l1_1.2 29.8 FALSE inc
eef1a1l1_1.3 49.8 FALSE dec
eif2s1b 34.6 FALSE inc
eif4e2 4.8 FALSE inc
eif4ea_1.1 45.9 FALSE dec
eif4ebp2 3.4 FALSE dec
eif4enif1_1.3 32.6 FALSE dec
gfm2 2.8 FALSE inc
gspt1 33.8 FALSE inc
mettl17_1.4 39.9 FALSE inc
mrpl15 52.5 FALSE inc
mrpl20 29.4 FALSE inc
mrpl22 27.4 FALSE inc
mrpl27 42.3 FALSE inc
mrpl3 39.8 FALSE inc
mrpl30 34.5 FALSE inc
mrpl4_1.2 36.5 FALSE inc
mrpl42 40.8 FALSE inc
mrpl43 36.3 FALSE inc
mrpl45_2.2 31.9 FALSE inc
mrps10 29.9 FALSE inc
mrps15 30.5 FALSE inc
mrps16_2.1 39.0 FALSE inc
mrps18a 27.5 FALSE inc
mrps18b 26.3 FALSE inc
mrps18c 40.1 FALSE inc
mrps22_1.4 41.8 FALSE inc
msi2b_1.6 4.1 FALSE inc
msi2b_1.8 38.4 FALSE dec
mt-atp6 3.5 FALSE inc
mt-atp8 34.3 FALSE inc
mt-cyb 3.7 FALSE inc
mt-nd1 30.2 FALSE inc
mt-nd2 5.3 FALSE inc
mt-nd3 4.3 FALSE inc
mt-nd4 3.5 FALSE inc
mt-nd4l 29.3 FALSE inc
mt-nd5 6.9 FALSE U
mt-nd6 3.6 FALSE inc
ndufaf3 31.1 FALSE inc
ndufaf5 41.4 FALSE inc
ndufb11 33.8 FALSE inc
ndufb5 40.9 FALSE inc
ndufb6 26.8 FALSE inc
ndufb8 32.8 FALSE inc
ndufb9 39.6 FALSE inc
ndufs2 40.9 FALSE inc
pmpcb 24.4 FALSE inc
postnb_1.4 7.0 FALSE inc
ppa1b 29.1 FALSE inc
rpl32_2.1 25.0 FALSE inc
rpl36a_1.3 46.0 FALSE inc
rpl7a_1.1 5.9 FALSE inc
rps9_2.1 2.6 FALSE inc
rwdd1 31.5 FALSE inc
sdhb 40.8 FALSE inc
sdhc_1.2 29.1 FALSE inc
si:ch211-139a5.9_1.1 29.7 FALSE inc
si:dkey-151g10.6 3.5 FALSE inc
si:dkey-46g23.1_1.1 40.9 FALSE dec
slc25a55b 39.0 FALSE dec
slc8a2b 47.0 FALSE dec
soul4 49.9 FALSE dec
tnrc6c1_1.4 59.3 FALSE dec
trdn_1.4 57.1 FALSE dec
ucp2 53.2 FALSE inc
Figure 128: Table of the 42nd cluster content


Cluster 65 - 4 transcripts (~ 25% < 23.82 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 129: DR curves for the 43rd cluster
Figure 130: BMDplot for the 43rd cluster
id BMD.zSD TF trend
acin1a_1.1 43 FALSE inc
luc7l3 36 FALSE dec
pnisr_1.2 6 FALSE bell
pnn 30 FALSE dec
Figure 131: Table of the 43rd cluster content


Cluster 46 - 17 transcripts (~ 25% < 24.59 μg/L)

Driver GO terms : DNA replication

KEGG pathways : DNA replication, Fanconi anemia pathway, Homologous recombination, Mismatch repair, Nucleotide excision repair

Wikipathways : DNA replication, G1 to S cell cycle control

Figure 132: DR curves for the 44th cluster
Figure 133: BMDplot for the 44th cluster
id BMD.zSD TF trend
brca2 16.9 TRUE inc
ccnb1_1.2 24.6 FALSE inc
ccne2_1.3 32.5 FALSE inc
cdk2 25.8 TRUE inc
cdkn1ca 45.1 FALSE inc
dna2 34.7 FALSE inc
palb2_1.2 1.7 FALSE inc
rad51d 27.0 FALSE inc
rad54l 22.3 FALSE inc
rbbp8_1.2 5.2 FALSE inc
recql4 31.7 FALSE inc
rnaseh2a_1.2 33.2 FALSE inc
rpa1 48.3 FALSE inc
rpa2_1.2 43.2 FALSE inc
rpa3 30.9 FALSE inc
top1l 26.5 TRUE dec
top3b 28.0 FALSE dec
Figure 134: Table of the 44th cluster content


Cluster 61 - 6 transcripts (~ 25% < 24.94 μg/L)

Driver GO terms :

KEGG pathways : ATP-dependent chromatin remodeling

Wikipathways :

Figure 135: DR curves for the 45th cluster
Figure 136: BMDplot for the 45th cluster
id BMD.zSD TF trend
chd3_2.2 30.4 TRUE dec
chrac1_1.2 25.0 TRUE inc
gatad2b 24.9 TRUE dec
lin52_1.2 44.3 FALSE inc
rbbp4 36.7 TRUE inc
smarcb1b_1.3 2.9 FALSE inc
Figure 137: Table of the 45th cluster content


Cluster 6 - 27 transcripts (~ 25% < 24.96 μg/L)

Driver GO terms : ribosome biogenesis

KEGG pathways : Ribosome biogenesis in eukaryotes

Wikipathways :

Figure 138: DR curves for the 46th cluster
Figure 139: BMDplot for the 46th cluster
id BMD.zSD TF trend
aamp_1.2 27.2 FALSE inc
bms1_2.1 2.9 FALSE dec
emg1 48.1 FALSE inc
eri1_2.1 29.4 FALSE inc
exosc5_1.1 5.2 FALSE dec
exosc5_1.2 40.4 FALSE inc
exosc8 31.8 FALSE inc
glmna 34.4 FALSE inc
ncoa6_1.2 2.5 FALSE inc
ncoa6_1.3 32.4 FALSE dec
ngdn 42.8 FALSE inc
nmd3 48.1 FALSE inc
noc4l 43.0 FALSE inc
nop58 2.6 FALSE dec
pin4 37.4 FALSE inc
pno1 22.7 FALSE inc
rab5if 2.3 FALSE dec
ran 30.5 TRUE inc
rpl7a_1.1 5.9 FALSE inc
rrp7a 39.9 FALSE inc
snu13b 40.3 FALSE inc
trub2 31.9 FALSE inc
UTP14C 52.0 FALSE dec
utp6_3.1 39.3 FALSE inc
xrn1 35.5 FALSE dec
xrn2_1.2 28.1 TRUE dec
zgc:174888_1.2 33.9 FALSE inc
Figure 140: Table of the 46th cluster content


Cluster 28 - 5 transcripts (~ 25% < 25.16 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 141: DR curves for the 47th cluster
Figure 142: BMDplot for the 47th cluster
id BMD.zSD TF trend
actr8 44.5 TRUE inc
dsn1 29.9 FALSE inc
knl1 2.1 FALSE inc
si:dkey-6i22.5 31.2 FALSE inc
spc24 25.2 FALSE inc
Figure 143: Table of the 47th cluster content


Cluster 40 - 10 transcripts (~ 25% < 26.62 μg/L)

Driver GO terms : regulatory ncRNA-mediated gene silencing

KEGG pathways :

Wikipathways :

Figure 144: DR curves for the 48th cluster
Figure 145: BMDplot for the 48th cluster
id BMD.zSD TF trend
ago1 40.2 TRUE dec
ago2 28.4 TRUE dec
ago4 54.4 FALSE dec
dicer1_1.1 26.0 FALSE dec
eri1_2.1 29.4 FALSE inc
pum1_1.2 34.1 FALSE dec
si:dkey-46g23.1_1.1 40.9 FALSE dec
snd1_1.2 2.3 TRUE dec
tarbp2 24.4 FALSE dec
tnrc6c1_1.4 59.3 FALSE dec
Figure 146: Table of the 48th cluster content


Cluster 63 - 18 transcripts (~ 25% < 26.73 μg/L)

Driver GO terms :

KEGG pathways : Apelin signaling pathway

Wikipathways :

Figure 147: DR curves for the 49th cluster
Figure 148: BMDplot for the 49th cluster
id BMD.zSD TF trend
akt3a_1.2 37.9 FALSE dec
aplnr2 6.9 FALSE inc
cdh1_1.2 4.4 FALSE dec
gna11b 39.7 FALSE dec
gnai2a 4.1 FALSE dec
gnb1a 56.9 FALSE dec
gnb1b 30.4 FALSE dec
hdac4_1.2 34.3 TRUE dec
hdac5_1.2 35.1 TRUE dec
kras_1.2 37.2 FALSE dec
mef2cb_1.5 41.3 TRUE dec
mef2d_1.2 41.0 TRUE dec
mylkb_1.2 2.9 FALSE dec
pde3b 33.0 FALSE dec
ppargc1a 37.8 TRUE dec
si:dkey-222b8.1_2.1 30.3 TRUE dec
slc8a2b 47.0 FALSE dec
tfam 25.5 TRUE inc
Figure 149: Table of the 49th cluster content


Cluster 51 - 4 transcripts (~ 25% < 26.86 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 150: DR curves for the 50th cluster
Figure 151: BMDplot for the 50th cluster
id BMD.zSD TF trend
fam214a_2.1 40 FALSE dec
pak1ip1 24 FALSE inc
rsl24d1 33 FALSE inc
wdr18 28 FALSE inc
Figure 152: Table of the 50th cluster content