Report of the workflow results

1 The results as an interactive table

2 The results as sensitivity plots

Figure 1: Sensitivity plot of clusters summarised by BMD first quartile

Figure 2: Sensitivity plot of clusters summarised by BMD median with the interquartile range as an interval

3 The top 50 most sensitive clusters

Cluster 50 - 9 transcripts (~ 25% < 1.95 μg/L)

Driver GO terms :

KEGG pathways : Retinol metabolism

Wikipathways :

Curvesplot

Figure 3: DR curves for the 1st cluster

BMDplot

Figure 4: BMDplot for the 1st cluster

id	BMD.zSD	TF	trend
cyp27c1	7.3	FALSE	inc
cyp3c1_1.2	42.0	FALSE	inc
cyp3c3_2.1	1.2	FALSE	U
lrata	37.8	FALSE	inc
lratb.2	1.9	FALSE	inc
ugt1b1_1.2	3.8	FALSE	dec
ugt2a7_2.2	2.5	FALSE	dec
ugt2a7_3.1	1.7	FALSE	dec
zgc:77938	2.9	FALSE	dec

Figure 5: Table of the 1st cluster content

Cluster 66 - 4 transcripts (~ 25% < 2.06 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 6: DR curves for the 2nd cluster

BMDplot

Figure 7: BMDplot for the 2nd cluster

id	BMD.zSD	TF	trend
atg3	2.2	FALSE	U
pi4kaa	42.3	FALSE	dec
pik3c3_1.2	3.9	FALSE	inc
rab5ab	1.7	FALSE	dec

Figure 8: Table of the 2nd cluster content

Cluster 49 - 4 transcripts (~ 25% < 2.58 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 9: DR curves for the 3rd cluster

BMDplot

Figure 10: BMDplot for the 3rd cluster

id	BMD.zSD	TF	trend
glo1	45.4	FALSE	inc
mccc2	3.0	FALSE	U
sdsl	1.2	FALSE	dec
tdh2	36.5	FALSE	dec

Figure 11: Table of the 3rd cluster content

Cluster 17 - 32 transcripts (~ 25% < 2.64 μg/L)

Driver GO terms : lipid biosynthetic process

KEGG pathways : Steroid biosynthesis

Wikipathways : Cholesterol biosynthesis

Curvesplot

Figure 12: DR curves for the 4th cluster

BMDplot

Figure 13: BMDplot for the 4th cluster

id	BMD.zSD	TF	trend
acsl1b	2.18	FALSE	dec
alox12	3.38	FALSE	dec
cers5	2.59	FALSE	dec
crppa	18.97	FALSE	inc
cyp17a1	2.73	FALSE	dec
cyp27b1	3.01	FALSE	dec
dhcr7	2.41	FALSE	dec
ERG28	41.26	FALSE	dec
fdft1_1.2	1.49	FALSE	dec
fitm1l	27.73	FALSE	inc
fnta_1.2	1.88	FALSE	dec
fnta_1.3	30.02	FALSE	inc
gpam	30.83	FALSE	dec
hmgcs1_1.2	2.98	FALSE	dec
impad1	2.66	FALSE	dec
insig2	36.86	FALSE	dec
lss	0.49	FALSE	U
nus1	28.81	FALSE	dec
pisd_2.1	57.14	FALSE	dec
ptdss2_1.2	22.71	FALSE	dec
PYURF_1.1	7.37	FALSE	inc
sc5d	2.28	FALSE	dec
scap	37.09	FALSE	dec
sccpdha.1	1.98	FALSE	dec
scd	23.97	FALSE	inc
selenoi	3.77	FALSE	dec
si:dkey-205h13.1_1.2	3.42	FALSE	inc
si:dkey-91i10.3	3.26	FALSE	dec
st6galnac4	23.11	FALSE	dec
tamm41	34.60	FALSE	inc
ugt8_2.1	4.12	FALSE	dec
zgc:77375	34.02	FALSE	dec

Figure 14: Table of the 4th cluster content

Cluster 52 - 34 transcripts (~ 25% < 2.98 μg/L)

Driver GO terms : cellular lipid metabolic process

KEGG pathways :

Wikipathways :

Curvesplot

Figure 15: DR curves for the 5th cluster

BMDplot

Figure 16: BMDplot for the 5th cluster

id	BMD.zSD	TF	trend
abcd1_1.2	4.68	FALSE	dec
acox3	3.06	FALSE	dec
acsl1b	2.18	FALSE	dec
alox12	3.38	FALSE	dec
cers5	2.59	FALSE	dec
cpt1aa_1.2	2.96	FALSE	dec
crppa	18.97	FALSE	inc
enpp7.1_3.1	0.84	FALSE	U
fa2h_1.3	1.67	FALSE	dec
fitm1l	27.73	FALSE	inc
gba2_1.2	1.39	FALSE	dec
gpam	30.83	FALSE	dec
hexb_1.3	39.70	FALSE	dec
impad1	2.66	FALSE	dec
mboat2a	24.39	FALSE	dec
mtmr3_2.2	17.77	FALSE	dec
mtmr7a_2.1	1.61	FALSE	inc
nus1	28.81	FALSE	dec
pisd_2.1	57.14	FALSE	dec
plcg2_1.2	4.02	FALSE	dec
proca1	3.66	FALSE	inc
ptdss2_1.2	22.71	FALSE	dec
PYURF_1.1	7.37	FALSE	inc
sccpdha.1	1.98	FALSE	dec
scd	23.97	FALSE	inc
selenoi	3.77	FALSE	dec
si:dkey-205h13.1_1.2	3.42	FALSE	inc
smpd3	49.35	FALSE	dec
srd5a3	25.25	FALSE	inc
st6galnac4	23.11	FALSE	dec
tamm41	34.60	FALSE	inc
taz_1.4	35.85	FALSE	inc
ugt8_2.1	4.12	FALSE	dec
zgc:77375	34.02	FALSE	dec

Figure 17: Table of the 5th cluster content

Cluster 48 - 4 transcripts (~ 25% < 3.01 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 18: DR curves for the 6th cluster

BMDplot

Figure 19: BMDplot for the 6th cluster

id	BMD.zSD	TF	trend
cbfa2t3_1.2	2.5	FALSE	bell
ldb1b_1.2	31.6	TRUE	dec
lmo1_1.1	3.2	TRUE	inc
tcf3a_1.2	35.7	TRUE	dec

Figure 20: Table of the 6th cluster content

Cluster 68 - 29 transcripts (~ 25% < 3.03 μg/L)

Driver GO terms : muscle contraction

KEGG pathways : Motor proteins

Wikipathways :

Curvesplot

Figure 21: DR curves for the 7th cluster

BMDplot

Figure 22: BMDplot for the 7th cluster

id	BMD.zSD	TF	trend
atp2a1_1.1	42.98	FALSE	inc
BX936363.1	33.56	FALSE	dec
cald1a	4.63	FALSE	dec
cx39.9	27.78	FALSE	inc
dctn1a_1.2	35.74	FALSE	dec
dctn4_1.3	4.08	FALSE	bell
dynll2b	3.69	FALSE	inc
erp44	3.03	FALSE	dec
htr1d	2.67	FALSE	inc
kif1b_1.1	5.11	FALSE	dec
kifc1_1.2	26.20	FALSE	inc
kifc3_1.5	45.08	FALSE	dec
myhz1.1_2.1	2.79	FALSE	inc
myhz1.2_1.2	1.92	FALSE	inc
myhz1.3	4.89	FALSE	inc
mylpfa_1.2	4.62	FALSE	inc
myo1b_1.3	2.90	FALSE	dec
MYO1D	4.14	FALSE	dec
rock2a_1.2	3.57	FALSE	U
scn4ba	34.66	FALSE	dec
tnnc2	6.22	FALSE	inc
tnni2a.4_1.2	24.82	FALSE	inc
tnni4b.2	29.69	FALSE	inc
tnnt1_1.2	0.16	FALSE	bell
tnnt1_1.3	51.02	FALSE	inc
tnnt3b_1.4	3.91	FALSE	inc
tnnt3b_1.5	1.94	FALSE	inc
tpma_1.3	49.56	FALSE	inc
tubb4b_1.2	2.47	FALSE	dec

Figure 23: Table of the 7th cluster content

Cluster 56 - 29 transcripts (~ 25% < 3.08 μg/L)

Driver GO terms : carbohydrate metabolic process

KEGG pathways : N-Glycan biosynthesis, Various types of N-glycan biosynthesis

Wikipathways :

Curvesplot

Figure 24: DR curves for the 8th cluster

BMDplot

Figure 25: BMDplot for the 8th cluster

id	BMD.zSD	TF	trend
agla_1.1	3.0	FALSE	dec
b4galt6	38.5	FALSE	dec
CABZ01079192.1	1.7	FALSE	dec
chia.1	0.3	FALSE	U
CR759923.1_1.4	2.2	FALSE	inc
CR774178.2	5.1	FALSE	dec
eno1a_1.2	5.3	FALSE	inc
ganab	34.4	FALSE	dec
GANAB_1.2	2.6	FALSE	dec
gcgra_2.1	3.5	FALSE	dec
hexa_1.1	30.8	FALSE	dec
hexb_1.3	39.7	FALSE	dec
hkdc1_2.1	3.1	FALSE	dec
insrb	35.5	FALSE	dec
kctd10	4.7	FALSE	U
lancl1	1.9	FALSE	inc
man1a1	36.4	FALSE	dec
man1b1b	36.7	FALSE	dec
MAN1C1_1.2	29.0	FALSE	dec
man2a1	3.1	FALSE	dec
mgat5	35.6	FALSE	dec
myorg	3.3	FALSE	dec
pdk1	32.3	FALSE	dec
pgk1	36.4	FALSE	inc
phkb_1.4	4.6	FALSE	inc
phkg1b_1.2	42.1	FALSE	inc
phkg2	4.6	FALSE	U
srd5a3	25.2	FALSE	inc
st6galnac4	23.1	FALSE	dec

Figure 26: Table of the 8th cluster content

Cluster 64 - 36 transcripts (~ 25% < 3.23 μg/L)

Driver GO terms : protein glycosylation

KEGG pathways : N-Glycan biosynthesis, Protein processing in endoplasmic reticulum, Various types of N-glycan biosynthesis

Wikipathways :

Curvesplot

Figure 27: DR curves for the 9th cluster

BMDplot

Figure 28: BMDplot for the 9th cluster

id	BMD.zSD	TF	trend
alg11_1.2	23.4	FALSE	dec
atf6	30.3	TRUE	dec
calr3b	4.1	FALSE	dec
canx	4.1	FALSE	dec
crppa	19.0	FALSE	inc
dnajb11	2.9	FALSE	dec
dnajc1	33.8	TRUE	inc
dnajc5aa	39.5	FALSE	dec
eif2s1b	34.6	FALSE	inc
ext1c_1.1	1.5	FALSE	inc
ganab	34.4	FALSE	dec
GANAB_1.2	2.6	FALSE	dec
hexb_1.3	39.7	FALSE	dec
hsp70l	68.6	FALSE	inc
hspa1b	20.5	TRUE	inc
march6_1.2	39.1	FALSE	dec
mgat5	35.6	FALSE	dec
mlec	2.9	FALSE	dec
ogt.1_2.1	2.9	FALSE	inc
pdia3_1.2	3.0	FALSE	dec
pdia6	5.5	FALSE	dec
pomgnt1_1.2	33.9	FALSE	inc
pomgnt1_2.1	36.1	FALSE	inc
pomt2	29.4	FALSE	inc
rnf185_1.2	28.7	FALSE	inc
RNF5	31.9	FALSE	dec
rpn1_1.2	3.3	FALSE	dec
rpn2_1.1	4.0	FALSE	dec
sec61b_1.2	3.2	FALSE	dec
selenos	3.2	FALSE	U
srd5a3	25.2	FALSE	inc
ssr2_1.2	2.8	FALSE	dec
st3gal7	2.8	FALSE	dec
st6galnac4	23.1	FALSE	dec
stt3b	3.3	FALSE	dec
xbp1_1.2	48.4	TRUE	inc

Figure 29: Table of the 9th cluster content

Cluster 29 - 30 transcripts (~ 25% < 3.31 μg/L)

Driver GO terms : RNA splicing, via transesterification reactions

KEGG pathways : Spliceosome

Wikipathways :

Curvesplot

Figure 30: DR curves for the 10th cluster

BMDplot

Figure 31: BMDplot for the 10th cluster

id	BMD.zSD	TF	trend
gemin2	32.3	FALSE	inc
gemin8_2.1	42.5	FALSE	dec
hnrnpa1b_1.2	2.2	FALSE	inc
hnrnpk_1.3	59.0	FALSE	dec
hnrnpm_1.3	2.0	FALSE	bell
hnrnpm_1.4	33.9	FALSE	dec
hnrnpua	45.0	FALSE	dec
hsp70l	68.6	FALSE	inc
hspa1b	20.5	TRUE	inc
LSM2_1.4	3.2	FALSE	dec
lsm5_1.2	4.4	FALSE	inc
pcbp4_1.1	2.5	FALSE	dec
puf60a_1.3	3.5	TRUE	inc
rbm15_2.1	35.7	TRUE	dec
rbm4.2	1.8	FALSE	bell
rbm4.3	24.1	FALSE	dec
rbm5_1.2	36.6	FALSE	dec
rp9_1.3	3.2	FALSE	inc
sf1_1.2	41.2	FALSE	dec
sf3b6	32.7	FALSE	inc
snrnp25	29.2	FALSE	inc
snrnp27	42.6	FALSE	inc
snrpd2	57.0	FALSE	inc
snrpg	40.8	FALSE	inc
snu13b	40.3	FALSE	inc
srsf5b_1.1	3.2	FALSE	bell
taf15_1.1	1.4	FALSE	dec
thoc1	32.0	FALSE	inc
wbp11_1.1	33.1	FALSE	dec
zgc:55733_1.2	33.6	TRUE	inc

Figure 32: Table of the 10th cluster content

Cluster 34 - 13 transcripts (~ 25% < 3.34 μg/L)

Driver GO terms : purine-containing compound biosynthetic process

KEGG pathways : Nucleotide metabolism, Purine metabolism

Wikipathways :

Curvesplot

Figure 33: DR curves for the 11th cluster

BMDplot

Figure 34: BMDplot for the 11th cluster

id	BMD.zSD	TF	trend
acsl1b	2.2	FALSE	dec
adka_1.2	3.3	FALSE	dec
adkb_1.2	54.6	FALSE	inc
ak1	6.3	FALSE	inc
ampd3b	3.0	FALSE	dec
atp5f1c	24.5	FALSE	inc
impdh1b_1.2	33.6	FALSE	dec
mt-atp6	3.5	FALSE	inc
mt-atp8	34.3	FALSE	inc
paics_1.1	3.1	FALSE	dec
pde3b	33.0	FALSE	dec
si:ch73-265d7.2	5.1	FALSE	inc
zgc:110540	25.4	FALSE	inc

Figure 35: Table of the 11th cluster content

Cluster 66 - 4 transcripts (~ 25% < 2.06 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 36: DR curves for the 12th cluster

BMDplot

Figure 37: BMDplot for the 12th cluster

id	BMD.zSD	TF	trend
atg3	2.2	FALSE	U
pi4kaa	42.3	FALSE	dec
pik3c3_1.2	3.9	FALSE	inc
rab5ab	1.7	FALSE	dec

Figure 38: Table of the 12th cluster content

Cluster 55 - 52 transcripts (~ 25% < 3.53 μg/L)

Driver GO terms :

KEGG pathways : Regulation of actin cytoskeleton, Salmonella infection, Tight junction

Wikipathways :

Curvesplot

Figure 39: DR curves for the 13th cluster

BMDplot

Figure 40: BMDplot for the 13th cluster

id	BMD.zSD	TF	trend
abi1b_1.2	49.3	FALSE	dec
acbd3	27.1	FALSE	dec
ACBD3	2.6	FALSE	dec
actb2_1.2	3.8	TRUE	dec
actr2a	4.6	FALSE	dec
actr2b	5.2	FALSE	dec
afdna_1.1	45.2	FALSE	dec
akt3a_1.2	37.9	FALSE	dec
arf2a_1.1	2.6	FALSE	U
arf2a_1.2	3.0	FALSE	dec
arhgap35a	34.2	TRUE	dec
braf_1.2	2.8	FALSE	bell
cldn11a	46.6	FALSE	inc
cldna	2.9	FALSE	dec
cldnk	3.4	FALSE	inc
dctn1a_1.2	35.7	FALSE	dec
dctn4_1.3	4.1	FALSE	bell
dlg1l_1.3	32.7	FALSE	dec
dlg1l_1.4	4.1	FALSE	dec
dnm2a_1.2	2.2	FALSE	dec
dynll2b	3.7	FALSE	inc
enah_1.2	5.5	FALSE	U
enah_1.3	38.4	FALSE	inc
ezra	3.1	FALSE	dec
ezrb_1.3	4.2	TRUE	dec
fgd1_1.4	39.3	FALSE	dec
fyco1a_1.2	3.9	FALSE	dec
hdr_1.2	2.0	FALSE	dec
itgb8	49.1	FALSE	dec
jam2a_1.3	38.9	FALSE	inc
kpna1	2.8	FALSE	bell
kpna3	2.5	FALSE	dec
kras_1.2	37.2	FALSE	dec
llgl2_1.3	3.9	FALSE	dec
map3k1	5.2	FALSE	dec
mapk14b_1.3	57.9	FALSE	dec
myh9b_1.2	3.6	FALSE	dec
mylkb_1.2	2.9	FALSE	dec
pak4	4.1	FALSE	dec
pak6a	43.7	FALSE	dec
pard6b	7.5	FALSE	dec
ppp1r12a	31.7	FALSE	dec
ppp2r2bb_1.3	4.7	FALSE	bell
ppp2r2d	21.2	FALSE	dec
rab5aa	36.9	FALSE	dec
rock2a_1.2	3.6	FALSE	U
scrib_1.3	38.3	FALSE	dec
tcf7l1a_1.2	34.9	TRUE	dec
tcf7l1b_1.1	5.1	TRUE	dec
tjap1	32.4	FALSE	dec
tubb4b_1.2	2.5	FALSE	dec
zgc:112437	41.2	FALSE	inc

Figure 41: Table of the 13th cluster content

Cluster 32 - 45 transcripts (~ 25% < 3.64 μg/L)

Driver GO terms : RNA splicing

KEGG pathways : Spliceosome

Wikipathways :

Curvesplot

Figure 42: DR curves for the 14th cluster

BMDplot

Figure 43: BMDplot for the 14th cluster

id	BMD.zSD	TF	trend
clk2a_1.1	7.0	FALSE	dec
ddx5_1.1	2.5	TRUE	dec
ddx5_1.4	4.0	TRUE	inc
gemin2	32.3	FALSE	inc
gemin8_2.1	42.5	FALSE	dec
hmga1a_1.1	3.6	TRUE	dec
hmga1a_1.2	2.8	TRUE	dec
hmga1a_1.3	4.9	TRUE	inc
hnrnpa1b_1.2	2.2	FALSE	inc
hnrnpk_1.3	59.0	FALSE	dec
hnrnpm_1.3	2.0	FALSE	bell
hnrnpm_1.4	33.9	FALSE	dec
hnrnpua	45.0	FALSE	dec
hsp70l	68.6	FALSE	inc
hspa1b	20.5	TRUE	inc
pcbp4_1.1	2.5	FALSE	dec
ppil1	34.7	FALSE	inc
prpf18_1.2	45.1	FALSE	dec
ptbp3	20.6	FALSE	dec
puf60a_1.3	3.5	TRUE	inc
qkia_1.2	32.5	FALSE	dec
rbfox1l_1.1	35.5	FALSE	inc
rbfox1l_2.1	31.9	FALSE	inc
rbm15_2.1	35.7	TRUE	dec
rbm4.2	1.8	FALSE	bell
rbm4.3	24.1	FALSE	dec
rbm5_1.2	36.6	FALSE	dec
rp9_1.3	3.2	FALSE	inc
rtcb_1.2	3.9	FALSE	U
sf1_1.2	41.2	FALSE	dec
si:dkey-67c22.2_1.2	27.8	FALSE	dec
slu7_1.2	4.0	FALSE	dec
snrnp25	29.2	FALSE	inc
snrnp27	42.6	FALSE	inc
snu13b	40.3	FALSE	inc
srsf3b_1.1	52.5	FALSE	dec
srsf5b_1.1	3.2	FALSE	bell
taf15_1.1	1.4	FALSE	dec
thoc1	32.0	FALSE	inc
thrap3b_1.4	46.3	FALSE	dec
thrap3b_1.5	35.7	FALSE	dec
tsen2	3.3	FALSE	inc
tssc4_1.2	4.8	FALSE	inc
wbp11_1.1	33.1	FALSE	dec
zgc:55733_1.2	33.6	TRUE	inc

Figure 44: Table of the 14th cluster content

Cluster 41 - 13 transcripts (~ 25% < 3.66 μg/L)

Driver GO terms :

KEGG pathways : Vascular smooth muscle contraction

Wikipathways :

Curvesplot

Figure 45: DR curves for the 15th cluster

BMDplot

Figure 46: BMDplot for the 15th cluster

id	BMD.zSD	TF	trend
adma	38.2	FALSE	inc
braf_1.2	2.8	FALSE	bell
cald1b_1.2	23.7	FALSE	dec
foxo3b	39.2	TRUE	dec
lsp1a	4.3	FALSE	dec
mapk3	24.9	FALSE	dec
mylkb_1.2	2.9	FALSE	dec
ppp1r12a	31.7	FALSE	dec
proca1	3.7	FALSE	inc
rock2a_1.2	3.6	FALSE	U
si:ch73-265d7.2	5.1	FALSE	inc
stmn1a_1.2	33.9	FALSE	inc
stmn1a_1.3	21.2	FALSE	inc

Figure 47: Table of the 15th cluster content

Cluster 33 - 42 transcripts (~ 25% < 3.68 μg/L)

Driver GO terms : canonical NF-kappaB signal transduction

KEGG pathways : Apoptosis, C-type lectin receptor signaling pathway, MAPK signaling pathway

Wikipathways :

Curvesplot

Figure 48: DR curves for the 16th cluster

BMDplot

Figure 49: BMDplot for the 16th cluster

id	BMD.zSD	TF	trend
akt3a_1.2	37.91	FALSE	dec
arf2b_1.2	3.69	FALSE	dec
birc5a	25.59	TRUE	inc
braf_1.2	2.79	FALSE	bell
cacng1a	30.61	FALSE	inc
cts12	52.43	FALSE	dec
ctsh	33.75	FALSE	inc
ctss2.2	58.70	FALSE	inc
cylda_1.2	2.29	FALSE	inc
eif2s1b	34.59	FALSE	inc
hdr_1.2	2.03	FALSE	dec
hsp70l	68.64	FALSE	inc
hspa1b	20.47	TRUE	inc
ikbkg_1.1	2.06	TRUE	dec
ikbkg_1.2	2.42	TRUE	bell
insrb	35.55	FALSE	dec
irf2a_1.2	3.10	TRUE	inc
irf7_1.2	23.10	TRUE	inc
jund	42.72	TRUE	dec
kras_1.2	37.23	FALSE	dec
ksr1b_1.4	37.30	FALSE	inc
lamtor3	33.76	FALSE	inc
lmnb2	20.38	FALSE	dec
map3k1	5.24	FALSE	dec
map3k14a	35.23	FALSE	inc
map4k6	0.79	FALSE	bell
mapk14b_1.3	57.92	FALSE	dec
mcl1a	24.25	FALSE	inc
mef2cb_1.5	41.30	TRUE	dec
mtdha_1.2	1.63	FALSE	dec
n4bp1	31.11	FALSE	dec
plcg2_1.2	4.02	FALSE	dec
ppm1ba	32.96	FALSE	dec
ppm1bb	28.92	FALSE	dec
ptpn11a_1.2	3.08	FALSE	dec
ptpn13_1.5	0.84	FALSE	dec
rap1b	3.67	FALSE	dec
rps6ka2	4.53	FALSE	bell
s100b	27.44	FALSE	inc
scaf11_1.1	37.16	FALSE	dec
taok1a_1.2	39.92	FALSE	dec
taok2b	39.79	FALSE	dec

Figure 50: Table of the 16th cluster content

Cluster 57 - 24 transcripts (~ 25% < 3.69 μg/L)

Driver GO terms : COPII-coated vesicle budding

KEGG pathways : Protein processing in endoplasmic reticulum

Wikipathways :

Curvesplot

Figure 51: DR curves for the 17th cluster

BMDplot

Figure 52: BMDplot for the 17th cluster

id	BMD.zSD	TF	trend
atf6	30.3	TRUE	dec
calr3b	4.1	FALSE	dec
canx	4.1	FALSE	dec
dnajb11	2.9	FALSE	dec
dnajc1	33.8	TRUE	inc
dnajc5aa	39.5	FALSE	dec
eif2s1b	34.6	FALSE	inc
ganab	34.4	FALSE	dec
GANAB_1.2	2.6	FALSE	dec
hsp70l	68.6	FALSE	inc
hspa1b	20.5	TRUE	inc
march6_1.2	39.1	FALSE	dec
pdia3_1.2	3.0	FALSE	dec
pdia6	5.5	FALSE	dec
rnf185_1.2	28.7	FALSE	inc
RNF5	31.9	FALSE	dec
sar1ab	41.5	FALSE	inc
sar1b	3.8	FALSE	dec
sec23a	5.0	FALSE	dec
sec31b_1.2	37.0	FALSE	dec
sec61b_1.2	3.2	FALSE	dec
selenos	3.2	FALSE	U
ssr2_1.2	2.8	FALSE	dec
xbp1_1.2	48.4	TRUE	inc

Figure 53: Table of the 17th cluster content

Cluster 13 - 49 transcripts (~ 25% < 3.75 μg/L)

Driver GO terms : protein folding

KEGG pathways : Protein processing in endoplasmic reticulum

Wikipathways :

Curvesplot

Figure 54: DR curves for the 18th cluster

BMDplot

Figure 55: BMDplot for the 18th cluster

id	BMD.zSD	TF	trend
ahsa1a_1.3	4.51	FALSE	inc
apaf1_1.2	0.42	FALSE	U
atf6	30.28	TRUE	dec
CABZ01080568.1	17.80	FALSE	inc
calr3b	4.13	FALSE	dec
canx	4.14	FALSE	dec
cct2_1.1	6.77	FALSE	inc
cct3	36.08	FALSE	inc
cct4	36.43	FALSE	inc
cct5	38.40	FALSE	inc
cct6a_1.3	37.45	FALSE	inc
cct7	49.62	FALSE	inc
cct8_1.2	3.13	FALSE	inc
dnajb11	2.88	FALSE	dec
dnajc1	33.78	TRUE	inc
dnajc18	3.75	FALSE	inc
dnajc5aa	39.49	FALSE	dec
eif2s1b	34.59	FALSE	inc
erp44	3.03	FALSE	dec
ganab	34.36	FALSE	dec
GANAB_1.2	2.64	FALSE	dec
hsp70.1_1.2	52.68	FALSE	inc
hsp70l	68.64	FALSE	inc
hsp90aa1.1	17.69	FALSE	inc
hspa1b	20.47	TRUE	inc
hspa4b_2.1	57.99	FALSE	inc
hspa8_2.1	51.24	FALSE	inc
hsph1	4.29	FALSE	inc
march6_1.2	39.13	FALSE	dec
p4hb_1.1	2.25	FALSE	dec
pdia3_1.2	2.97	FALSE	dec
pdia6	5.55	FALSE	dec
pfdn2	32.09	FALSE	inc
pfdn4	41.34	FALSE	inc
pfdn5_2.1	40.91	FALSE	inc
pfdn5_3.1	28.01	TRUE	inc
ppiaa	27.20	FALSE	inc
ppid_1.2	25.06	TRUE	inc
rnf185_1.2	28.70	FALSE	inc
RNF5	31.93	FALSE	dec
rpap3	37.41	FALSE	inc
sec61b_1.2	3.23	FALSE	dec
selenos	3.23	FALSE	U
si:ch211-131k2.3	18.50	FALSE	inc
ssr2_1.2	2.82	FALSE	dec
st13	2.78	FALSE	dec
tor1_1.2	2.53	FALSE	dec
wdr83os_1.1	25.27	FALSE	inc
xbp1_1.2	48.44	TRUE	inc

Figure 56: Table of the 18th cluster content

Cluster 24 - 13 transcripts (~ 25% < 4.08 μg/L)

Driver GO terms : Notch signaling pathway

KEGG pathways : Notch signaling pathway

Wikipathways :

Curvesplot

Figure 57: DR curves for the 19th cluster

BMDplot

Figure 58: BMDplot for the 19th cluster

id	BMD.zSD	TF	trend
chsy1	43.3	FALSE	dec
dlb	4.1	FALSE	inc
dtx4a	47.1	FALSE	dec
egfl6_1.1	39.9	FALSE	inc
gmds_1.1	5.8	FALSE	dec
gmds_1.3	3.1	FALSE	dec
lfng_1.2	24.1	FALSE	inc
notch1a_1.2	2.3	TRUE	inc
notch1b_1.3	48.6	FALSE	dec
nr2f2_1.2	42.5	TRUE	dec
plvapb	57.5	FALSE	inc
psen2	1.9	FALSE	dec
tcima	31.7	FALSE	inc

Figure 59: Table of the 19th cluster content

Cluster 30 - 49 transcripts (~ 25% < 4.09 μg/L)

Driver GO terms : mRNA processing

KEGG pathways : mRNA surveillance pathway

Wikipathways : mRNA processing

Curvesplot

Figure 60: DR curves for the 20th cluster

BMDplot

Figure 61: BMDplot for the 20th cluster

id	BMD.zSD	TF	trend
celf2_1.2	32.7	FALSE	dec
celf2_1.4	27.6	FALSE	dec
clk2a_1.1	7.0	FALSE	dec
cpsf3	57.2	FALSE	inc
cpsf6_1.2	2.1	FALSE	dec
cstf2_1.2	3.7	FALSE	inc
ern1	60.3	TRUE	dec
FNDC10	4.5	FALSE	inc
gemin2	32.3	FALSE	inc
gemin8_2.1	42.5	FALSE	dec
hnrnpa1b_1.2	2.2	FALSE	inc
hnrnpaba_1.3	7.9	FALSE	dec
hnrnpk_1.3	59.0	FALSE	dec
hnrnpm_1.3	2.0	FALSE	bell
hnrnpm_1.4	33.9	FALSE	dec
hnrnpua	45.0	FALSE	dec
msi2b_1.6	4.1	FALSE	inc
msi2b_1.8	38.4	FALSE	dec
pabpn1_1.1	4.6	FALSE	inc
pabpn1_1.3	28.7	FALSE	dec
papolg	2.3	FALSE	bell
pcbp4_1.1	2.5	FALSE	dec
ppp2r2bb_1.3	4.7	FALSE	bell
ppp2r2d	21.2	FALSE	dec
ppp2r3c	26.2	FALSE	inc
ptbp3	20.6	FALSE	dec
puf60a_1.3	3.5	TRUE	inc
qkia_1.2	32.5	FALSE	dec
rbm15_2.1	35.7	TRUE	dec
rbm26_1.2	32.0	FALSE	dec
rbm27	33.7	FALSE	dec
rbm39a_1.4	1.4	TRUE	dec
rbm39a_1.5	3.9	TRUE	inc
rbm39b_1.1	5.1	FALSE	inc
rbm4.2	1.8	FALSE	bell
rbm4.3	24.1	FALSE	dec
rbm5_1.2	36.6	FALSE	dec
sf1_1.2	41.2	FALSE	dec
smn1_1.2	37.1	FALSE	inc
smndc1_1.1	51.3	FALSE	inc
smx5	29.4	FALSE	inc
snrnp25	29.2	FALSE	inc
snu13b	40.3	FALSE	inc
srsf5b_1.1	3.2	FALSE	bell
taf15_1.1	1.4	FALSE	dec
thoc7	32.7	FALSE	inc
tssc4_1.2	4.8	FALSE	inc
xrn2_1.2	28.1	TRUE	dec
zc3h6	44.1	FALSE	dec

Figure 62: Table of the 20th cluster content

Cluster 70 - 4 transcripts (~ 25% < 4.13 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 63: DR curves for the 21st cluster

BMDplot

Figure 64: BMDplot for the 21st cluster

id	BMD.zSD	TF	trend
eif4a2_1.2	4.2	FALSE	inc
eif4ba_1.4	41.6	FALSE	dec
eif4bb_1.3	4.0	FALSE	dec
eif4g1a_1.3	4.6	FALSE	U

Figure 65: Table of the 21st cluster content

Cluster 16 - 37 transcripts (~ 25% < 4.18 μg/L)

Driver GO terms : chromatin organization

KEGG pathways : ATP-dependent chromatin remodeling

Wikipathways :

Curvesplot

Figure 66: DR curves for the 22nd cluster

BMDplot

Figure 67: BMDplot for the 22nd cluster

id	BMD.zSD	TF	trend
asf1ba	41.2	FALSE	inc
baz1b_1.2	52.9	TRUE	dec
brd1b	42.2	FALSE	dec
brd8_1.3	6.9	FALSE	dec
brd8_1.4	4.2	FALSE	inc
brpf1_1.1	42.5	FALSE	dec
cbx1b_1.3	3.4	FALSE	inc
cbx3b	3.1	FALSE	inc
cbx5_1.2	45.2	TRUE	inc
chd7_1.3	54.7	TRUE	dec
chrac1_1.2	25.0	TRUE	inc
dek_1.2	36.7	TRUE	inc
ep400_1.2	3.4	TRUE	inc
h1-10	41.0	FALSE	inc
hdac4_1.2	34.3	TRUE	dec
hdac5_1.2	35.1	TRUE	dec
hnrnpua	45.0	FALSE	dec
ing4	3.1	TRUE	inc
kat6a	42.2	TRUE	dec
l3mbtl2_1.3	34.9	TRUE	inc
lmnb2	20.4	FALSE	dec
mbd1a_1.3	33.8	FALSE	dec
meaf6_1.2	2.6	TRUE	inc
morf4l1	31.8	TRUE	inc
nap1l1	3.2	FALSE	dec
nap1l4a_2.2	53.5	FALSE	inc
npm3_1.2	58.9	TRUE	inc
nsd3_1.3	45.4	TRUE	dec
seta	38.7	FALSE	inc
setb_1.1	2.3	TRUE	inc
si:ch211-103n10.5	24.5	FALSE	dec
smarcb1b_1.3	2.9	FALSE	inc
smyd1b_1.2	34.9	TRUE	inc
smyd4	37.1	FALSE	inc
ttn.2_1.4	2.6	FALSE	inc
waca	40.0	TRUE	dec
yeats4	48.8	TRUE	inc

Figure 68: Table of the 22nd cluster content

Cluster 12 - 47 transcripts (~ 25% < 4.19 μg/L)

Driver GO terms : generation of precursor metabolites and energy

KEGG pathways : Cardiac muscle contraction, Oxidative phosphorylation, Arginine and proline metabolism

Wikipathways : Electron transport chain

Curvesplot

Figure 69: DR curves for the 23rd cluster

BMDplot

Figure 70: BMDplot for the 23rd cluster

id	BMD.zSD	TF	trend
agla_1.1	3.0	FALSE	dec
agmat	2.8	FALSE	dec
aldh2.1	57.4	FALSE	inc
aldh3a2b	3.0	FALSE	dec
arg2	24.5	FALSE	inc
atp1a3a	58.6	FALSE	dec
atp2a1_1.1	43.0	FALSE	inc
atp2a2b	3.3	FALSE	dec
atp2a3_1.3	2.8	FALSE	dec
atp5f1c	24.5	FALSE	inc
cacng1a	30.6	FALSE	inc
ckmb	30.6	FALSE	inc
coa6	4.6	FALSE	inc
cox11_1.2	32.8	FALSE	inc
eno1a_1.2	5.3	FALSE	inc
hacl1_1.2	3.5	FALSE	U
higd1a	41.2	FALSE	inc
hkdc1_2.1	3.1	FALSE	dec
insrb	35.5	FALSE	dec
mao	2.4	FALSE	dec
mt-atp6	3.5	FALSE	inc
mt-atp8	34.3	FALSE	inc
mt-co1	3.8	FALSE	inc
mt-co2	5.5	FALSE	inc
mt-co3	3.6	FALSE	inc
mt-nd2	5.3	FALSE	inc
oat_1.2	35.2	FALSE	inc
odc1_1.3	35.8	FALSE	inc
oxct1a_1.2	3.2	FALSE	inc
pgk1	36.4	FALSE	inc
phkb_1.4	4.6	FALSE	inc
phkg1b_1.2	42.1	FALSE	inc
phkg2	4.6	FALSE	U
ppa1b	29.1	FALSE	inc
pycr1b	31.6	FALSE	inc
sat1a.2_1.2	37.4	FALSE	inc
sat2b	26.9	FALSE	inc
sco1_1.1	44.6	FALSE	inc
sdhb	40.8	FALSE	inc
sdhc_1.2	29.1	FALSE	inc
si:ch211-139a5.9_1.1	29.7	FALSE	inc
slc25a55b	39.0	FALSE	dec
slc8a2b	47.0	FALSE	dec
smox_1.3	6.2	FALSE	inc
surf1	35.7	FALSE	inc
trdn_1.4	57.1	FALSE	dec
ucp2	53.2	FALSE	inc

Figure 71: Table of the 23rd cluster content

Cluster 15 - 37 transcripts (~ 25% < 4.2 μg/L)

Driver GO terms : sphingolipid metabolic process, transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG pathways : Sphingolipid metabolism, TGF-beta signaling pathway

Wikipathways :

Curvesplot

Figure 72: DR curves for the 24th cluster

BMDplot

Figure 73: BMDplot for the 24th cluster

id	BMD.zSD	TF	trend
acvr1ba	39.1	FALSE	dec
acvr1bb_1.2	27.0	FALSE	dec
acvr2ba_1.3	25.1	FALSE	dec
acvr2bb	39.5	FALSE	dec
asah2	1.3	FALSE	dec
b4galt6	38.5	FALSE	dec
bmpr2a	46.2	FALSE	dec
bmpr2b	39.1	FALSE	dec
cers2a_1.2	25.8	FALSE	dec
cers3a_1.2	1.7	FALSE	dec
cers5	2.6	FALSE	dec
flcn_1.2	3.6	FALSE	inc
hexb_1.3	39.7	FALSE	dec
hjv_1.2	32.3	FALSE	inc
kdsr_1.2	2.4	FALSE	dec
lats1_1.2	40.7	FALSE	dec
ldlrad4a_1.2	32.4	FALSE	dec
ldlrad4b	21.8	FALSE	dec
lemd3	35.5	FALSE	dec
nomo	33.6	FALSE	dec
plpp3	5.3	FALSE	dec
ppm1bb	28.9	FALSE	dec
rbm14a_2.1	4.2	FALSE	dec
sgpl1_1.1	2.6	FALSE	dec
si:dkey-222b8.1_2.1	30.3	TRUE	dec
skia	23.1	TRUE	dec
skib	2.9	FALSE	bell
skila_1.2	44.8	TRUE	dec
skila_1.3	44.0	TRUE	dec
skila_1.4	47.4	TRUE	dec
smad2_1.2	33.1	TRUE	dec
smad2_1.3	33.5	TRUE	dec
smurf2	28.0	TRUE	dec
SPHK1	36.0	FALSE	dec
sphk2	3.6	FALSE	dec
st6galnac4	23.1	FALSE	dec
ugt8_2.1	4.1	FALSE	dec

Figure 74: Table of the 24th cluster content

Cluster 26 - 32 transcripts (~ 25% < 4.36 μg/L)

Driver GO terms : carboxylic acid metabolic process

KEGG pathways : Biosynthesis of amino acids, Cysteine and methionine metabolism

Wikipathways :

Curvesplot

Figure 75: DR curves for the 25th cluster

BMDplot

Figure 76: BMDplot for the 25th cluster

id	BMD.zSD	TF	trend
abcd1_1.2	4.7	FALSE	dec
acox3	3.1	FALSE	dec
acsl1b	2.2	FALSE	dec
adi1	28.8	FALSE	inc
aldh1l1_2.1	2.9	FALSE	dec
alox12	3.4	FALSE	dec
apip	37.3	FALSE	inc
asdurf_1.2	40.5	FALSE	inc
aspg_1.3	14.0	FALSE	inc
azin1b	53.0	FALSE	inc
cad_1.2	27.1	FALSE	inc
cpt1aa_1.2	3.0	FALSE	dec
cth	32.7	TRUE	inc
eno1a_1.2	5.3	FALSE	inc
gclm	2.9	FALSE	dec
ggctb	35.5	FALSE	inc
gldc	25.7	FALSE	inc
glulb_1.1	36.3	FALSE	inc
glulb_1.2	30.2	FALSE	inc
got1_1.1	5.9	FALSE	dec
gpam	30.8	FALSE	dec
hkdc1_2.1	3.1	FALSE	dec
HPDL	28.3	FALSE	inc
insrb	35.5	FALSE	dec
ldhba	31.9	FALSE	inc
oat_1.2	35.2	FALSE	inc
pgk1	36.4	FALSE	inc
phgdh	17.9	FALSE	inc
psat1	9.3	FALSE	inc
pycr1b	31.6	FALSE	inc
scd	24.0	FALSE	inc
unknown.101	2.2	FALSE	dec

Figure 77: Table of the 25th cluster content

Cluster 8 - 81 transcripts (~ 25% < 4.39 μg/L)

Driver GO terms : canonical Wnt signaling pathway, embryonic organ morphogenesis

KEGG pathways : Adherens junction, Melanogenesis, Mitophagy - animal, mTOR signaling pathway, Ribosome biogenesis in eukaryotes, Wnt signaling pathway

Wikipathways : Non canonical Wnt pathway, Wnt Signaling Pathway, Wnt Signaling Pathway and Pluripotency

Curvesplot

Figure 78: DR curves for the 26th cluster

BMDplot

Figure 79: BMDplot for the 26th cluster

id	BMD.zSD	TF	trend
acp1_1.1	32.6	FALSE	inc
afdna_1.1	45.2	FALSE	dec
ahsa1a_1.3	4.5	FALSE	inc
akt3a_1.2	37.9	FALSE	dec
atg9a_1.4	43.4	FALSE	inc
bcl9_1.2	45.0	TRUE	dec
braf_1.2	2.8	FALSE	bell
cacybp	27.0	FALSE	inc
cdh1_1.2	4.4	FALSE	dec
chd7_1.3	54.7	TRUE	dec
chsy1	43.3	FALSE	dec
clul1_2.1	39.8	FALSE	dec
csnk1g2a_1.2	30.3	FALSE	dec
csnk2a2a	4.6	FALSE	inc
csnk2a4	1.0	FALSE	U
ctnnb1_1.1	32.8	TRUE	dec
ctnnd1_1.2	4.7	TRUE	dec
daam1a_1.2	51.7	FALSE	dec
depdc5_1.1	3.9	FALSE	inc
eif2s1b	34.6	FALSE	inc
eif4e2	4.8	FALSE	inc
fabp3	38.4	FALSE	inc
farp2_1.2	9.1	FALSE	U
furina_2.1	2.8	FALSE	dec
fzd1	2.6	FALSE	U
fzd10	42.4	FALSE	inc
grb10a	3.5	FALSE	dec
gsk3ba	22.3	TRUE	dec
gskip	3.9	FALSE	dec
hdac4_1.2	34.3	TRUE	dec
insrb	35.5	FALSE	dec
irs1	27.5	FALSE	dec
kctd10	4.7	FALSE	U
kras_1.2	37.2	FALSE	dec
lamtor3	33.8	FALSE	inc
ldlra_1.1	33.3	FALSE	dec
lrp5_1.2	4.4	FALSE	dec
mapkap1_1.2	19.0	FALSE	dec
mef2cb_1.5	41.3	TRUE	dec
meis1b_1.1	4.1	TRUE	inc
mon1a	2.0	FALSE	dec
nap1l1	3.2	FALSE	dec
nmd3	48.1	FALSE	inc
ntn1a_1.2	39.4	FALSE	dec
pbx4_1.2	23.0	TRUE	dec
ppm1ba	33.0	FALSE	dec
ppm1bb	28.9	FALSE	dec
ppp2r2bb_1.3	4.7	FALSE	bell
ptpn11a_1.2	3.1	FALSE	dec
pvrl2l	39.2	FALSE	dec
pygo2_1.2	36.3	FALSE	dec
rab5aa	36.9	FALSE	dec
ran	30.5	TRUE	inc
rap1b	3.7	FALSE	dec
rnf146_1.2	16.9	FALSE	dec
rock2a_1.2	3.6	FALSE	U
rps6ka2	4.5	FALSE	bell
sgk2b_1.2	2.3	FALSE	inc
si:ch211-195b13.1_1.2	5.5	FALSE	inc
si:ch73-22o12.1	36.6	FALSE	dec
si:dkey-1c11.1_1.2	1.7	FALSE	inc
si:dkey-222b8.1_2.1	30.3	TRUE	dec
skib	2.9	FALSE	bell
smoc1	5.2	FALSE	dec
smyd4	37.1	FALSE	inc
snu13b	40.3	FALSE	inc
sox11a	58.3	TRUE	dec
spry2	4.2	FALSE	inc
taz_1.4	35.9	FALSE	inc
tbl1xr1b	4.7	FALSE	dec
tcf7l1a_1.2	34.9	TRUE	dec
tcf7l1b_1.1	5.1	TRUE	dec
tcf7l2_1.10	42.3	TRUE	dec
tfap2c_1.2	1.6	TRUE	dec
tti1	27.0	FALSE	inc
usp8	31.4	FALSE	dec
vangl2	36.5	FALSE	dec
wnt4b_2.1	1.4	FALSE	bell
xrn1	35.5	FALSE	dec
xrn2_1.2	28.1	TRUE	dec
zgc:86598_1.2	27.0	TRUE	inc

Figure 80: Table of the 26th cluster content

Cluster 21 - 36 transcripts (~ 25% < 4.41 μg/L)

Driver GO terms : microtubule-based process

KEGG pathways :

Wikipathways :

Curvesplot

Figure 81: DR curves for the 27th cluster

BMDplot

Figure 82: BMDplot for the 27th cluster

id	BMD.zSD	TF	trend
alms1	2.8	FALSE	inc
cep192_1.2	40.0	FALSE	inc
cep57	3.2	FALSE	inc
cfap298	19.0	FALSE	inc
ckap5_1.2	8.2	FALSE	inc
cpeb2_1.1	3.2	FALSE	bell
cpeb3	34.9	FALSE	dec
CU929259.1	22.5	FALSE	dec
dynll2b	3.7	FALSE	inc
fyco1a_1.2	3.9	FALSE	dec
gas2l1_1.2	25.8	FALSE	dec
gas2l3	41.1	FALSE	dec
haus4	30.8	FALSE	inc
hnrnpua	45.0	FALSE	dec
kif1b_1.1	5.1	FALSE	dec
kif2c_1.3	39.0	FALSE	inc
kifc1_1.2	26.2	FALSE	inc
kifc3_1.5	45.1	FALSE	dec
map1ab_1.2	39.8	FALSE	dec
map4l_1.4	4.6	FALSE	bell
map7d2a_1.1	58.5	FALSE	dec
nckap5l	33.5	FALSE	dec
nusap1	37.1	FALSE	inc
plk1	45.8	FALSE	inc
rock2a_1.2	3.6	FALSE	U
si:ch73-217b7.1_1.2	35.1	FALSE	dec
si:dkey-57a22.11	1.9	FALSE	inc
tacc3_1.2	30.5	FALSE	inc
tppp2_2.1	42.5	FALSE	inc
tubb4b_1.2	2.5	FALSE	dec
tubgcp2	35.0	FALSE	inc
tubgcp4	3.4	FALSE	inc
tubgcp5	6.7	FALSE	inc
zgc:158640	32.8	FALSE	inc
zgc:86764_1.2	46.1	FALSE	inc
zgc:92429	35.7	FALSE	inc

Figure 83: Table of the 27th cluster content

Cluster 7 - 13 transcripts (~ 25% < 4.6 μg/L)

Driver GO terms : regulation of transcription elongation by RNA polymerase II

KEGG pathways :

Wikipathways :

Curvesplot

Figure 84: DR curves for the 28th cluster

BMDplot

Figure 85: BMDplot for the 28th cluster

id	BMD.zSD	TF	trend
cdc73_1.2	3.9	TRUE	U
cdk12_1.3	22.9	FALSE	dec
cdk8_2.1	40.9	TRUE	dec
ercc8_1.2	4.6	FALSE	inc
ints8_1.2	2.7	FALSE	inc
med10_1.1	47.1	TRUE	inc
med30	4.7	TRUE	inc
med31	42.6	TRUE	inc
med7_3.1	29.9	FALSE	inc
nelfe_1.2	43.9	FALSE	inc
polr2a	32.9	TRUE	dec
ssrp1b_1.3	2.7	TRUE	inc
supt6h	51.6	TRUE	dec

Figure 86: Table of the 28th cluster content

Cluster 14 - 61 transcripts (~ 25% < 4.86 μg/L)

Driver GO terms : DNA metabolic process, organic acid metabolic process

KEGG pathways : Base excision repair, DNA replication, 2-Oxocarboxylic acid metabolism, Biosynthesis of amino acids, Carbon metabolism, Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism

Wikipathways : DNA replication, TCA cycle

Curvesplot

Figure 87: DR curves for the 29th cluster

BMDplot

Figure 88: BMDplot for the 29th cluster

id	BMD.zSD	TF	trend
abcd1_1.2	4.7	FALSE	dec
aco1	3.4	FALSE	dec
acox3	3.1	FALSE	dec
acsl1b	2.2	FALSE	dec
acss2l	27.5	FALSE	inc
adi1	28.8	FALSE	inc
aldh1l1_2.1	2.9	FALSE	dec
alox12	3.4	FALSE	dec
asdurf_1.2	40.5	FALSE	inc
aspg_1.3	14.0	FALSE	inc
azin1b	53.0	FALSE	inc
brca2	16.9	TRUE	inc
cad_1.2	27.1	FALSE	inc
ccdc36	4.5	FALSE	inc
cdk2	25.8	TRUE	inc
cpt1aa_1.2	3.0	FALSE	dec
cs	4.6	FALSE	dec
cyp2ad3	33.4	FALSE	inc
cyp2ad6	29.1	FALSE	inc
dna2	34.7	FALSE	inc
dnmt3bb.1_2.1	6.1	FALSE	dec
eno1a_1.2	5.3	FALSE	inc
fam168a_1.2	36.1	FALSE	dec
fan1_1.1	45.8	FALSE	inc
fen1	32.4	FALSE	inc
gldc	25.7	FALSE	inc
glulb_1.1	36.3	FALSE	inc
glulb_1.2	30.2	FALSE	inc
gpam	30.8	FALSE	dec
hkdc1_2.1	3.1	FALSE	dec
hltf_1.2	35.4	TRUE	inc
hnrnpua	45.0	FALSE	dec
HPDL	28.3	FALSE	inc
idh2	3.7	FALSE	inc
insrb	35.5	FALSE	dec
isg20	4.0	FALSE	inc
mad2l2	56.6	TRUE	inc
mdh1aa_1.2	2.8	FALSE	inc
mnd1_1.2	52.5	FALSE	inc
nucks1a	39.3	FALSE	dec
oat_1.2	35.2	FALSE	inc
palb2_1.2	1.7	FALSE	inc
pcna	27.9	FALSE	inc
pdk1	32.3	FALSE	dec
pgk1	36.4	FALSE	inc
phgdh	17.9	FALSE	inc
pold2_1.2	26.1	FALSE	inc
prim1	29.1	FALSE	inc
psat1	9.3	FALSE	inc
pycr1b	31.6	FALSE	inc
rad51d	27.0	FALSE	inc
rbbp8_1.2	5.2	FALSE	inc
rev1_2.1	3.9	FALSE	inc
rnaseh2a_1.2	33.2	FALSE	inc
scd	24.0	FALSE	inc
sdhb	40.8	FALSE	inc
top1_1.4	34.2	FALSE	dec
top1l	26.5	TRUE	dec
ube2a_1.2	4.9	FALSE	inc
ube2al	38.9	FALSE	inc
unknown.76	24.1	FALSE	inc

Figure 89: Table of the 29th cluster content

Cluster 5 - 43 transcripts (~ 25% < 5.17 μg/L)

Driver GO terms : protein catabolic process

KEGG pathways : Proteasome

Wikipathways :

Curvesplot

Figure 90: DR curves for the 30th cluster

BMDplot

Figure 91: BMDplot for the 30th cluster

id	BMD.zSD	TF	trend
akirin2_1.2	38.0	FALSE	dec
anapc4_1.2	4.7	FALSE	inc
appbp2	40.1	FALSE	dec
arih2_1.1	2.7	FALSE	dec
azin1b	53.0	FALSE	inc
CR788324.2	33.2	FALSE	dec
cul2	30.5	FALSE	inc
desi1a	5.3	FALSE	inc
fbxo33	37.8	FALSE	dec
hectd3_1.2	2.7	FALSE	dec
kctd10	4.7	FALSE	U
kctd5a	25.2	FALSE	dec
lgmn_1.2	1.5	FALSE	U
oaz2b	45.6	FALSE	inc
pomp	37.3	FALSE	inc
ppt1_1.2	45.4	FALSE	inc
psma3	36.2	FALSE	inc
psma4	39.1	FALSE	inc
psma5_1.1	33.1	FALSE	inc
psma6b_1.2	45.4	FALSE	inc
psmb4	47.0	FALSE	inc
psmc1a_2.2	42.8	FALSE	inc
psmc4_1.2	38.8	FALSE	inc
psmd12	51.7	FALSE	inc
psmd13	39.2	FALSE	inc
psmd14	42.2	FALSE	inc
psmd2	5.1	FALSE	dec
psmd4a_1.2	47.9	FALSE	inc
psme3_1.2	47.1	FALSE	inc
psme4b_2.2	1.2	FALSE	bell
rnf146_1.2	16.9	FALSE	dec
rock2a_1.2	3.6	FALSE	U
uba7	1.8	FALSE	U
ube2a_1.2	4.9	FALSE	inc
ube2al	38.9	FALSE	inc
usp14	36.2	FALSE	inc
usp24_1.2	35.4	FALSE	dec
usp2a_1.4	38.0	FALSE	dec
usp2a_1.5	3.8	FALSE	inc
usp32	34.3	FALSE	dec
usp4	45.4	FALSE	dec
usp8	31.4	FALSE	dec
vps37c	32.4	FALSE	dec

Figure 92: Table of the 30th cluster content

Cluster 45 - 5 transcripts (~ 25% < 5.28 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 93: DR curves for the 31st cluster

BMDplot

Figure 94: BMDplot for the 31st cluster

id	BMD.zSD	TF	trend
oxsr1a	35.0	FALSE	dec
sec62	42.1	FALSE	dec
sec63	5.3	FALSE	dec
strada	2.1	FALSE	inc
STRADB	48.4	FALSE	dec

Figure 95: Table of the 31st cluster content

Cluster 20 - 38 transcripts (~ 25% < 6.37 μg/L)

Driver GO terms : ubiquitin-dependent protein catabolic process

KEGG pathways : Ubiquitin mediated proteolysis

Wikipathways :

Curvesplot

Figure 96: DR curves for the 32nd cluster

BMDplot

Figure 97: BMDplot for the 32nd cluster

id	BMD.zSD	TF	trend
anapc4_1.2	4.7	FALSE	inc
anapc5	23.6	FALSE	inc
appbp2	40.1	FALSE	dec
arih2_1.1	2.7	FALSE	dec
cbl	41.4	TRUE	dec
cdc34b	31.4	FALSE	dec
CR788324.2	33.2	FALSE	dec
cul2	30.5	FALSE	inc
fbxo33	37.8	FALSE	dec
hectd3_1.2	2.7	FALSE	dec
kctd10	4.7	FALSE	U
kctd5a	25.2	FALSE	dec
map3k1	5.2	FALSE	dec
nufip2	29.3	FALSE	dec
rnf146_1.2	16.9	FALSE	dec
sae1	39.0	FALSE	inc
trip12_1.2	27.9	FALSE	dec
uba1_1.1	45.7	FALSE	dec
uba1_1.2	45.5	FALSE	dec
uba7	1.8	FALSE	U
ube2a_1.2	4.9	FALSE	inc
ube2al	38.9	FALSE	inc
ube2c_2.1	38.1	FALSE	inc
ube2d2_1.3	7.3	FALSE	bell
ube2d4	30.6	FALSE	dec
ube2ka	37.7	FALSE	inc
ube2l3b_1.1	2.4	FALSE	U
UBE2M_1.4	35.4	FALSE	inc
UBE2M_1.5	30.8	FALSE	dec
usp24_1.2	35.4	FALSE	dec
usp2a_1.4	38.0	FALSE	dec
usp2a_1.5	3.8	FALSE	inc
usp32	34.3	FALSE	dec
usp4	45.4	FALSE	dec
usp48_1.2	37.7	FALSE	inc
usp8	31.4	FALSE	dec
vps37c	32.4	FALSE	dec
wdr26b	6.1	FALSE	dec

Figure 98: Table of the 32nd cluster content

Cluster 1 - 162 transcripts (~ 25% < 6.69 μg/L)

Driver GO terms : ribosomal small subunit assembly, translation, embryo development ending in birth or egg hatching, ribonucleoprotein complex biogenesis, DNA geometric change, DNA replication

KEGG pathways : Ribosome, Cell cycle, DNA replication

Wikipathways : Cytoplasmic ribosomal proteins, Cell cycle, DNA replication, G1 to S cell cycle control

Curvesplot

Figure 99: DR curves for the 33rd cluster

BMDplot

Figure 100: BMDplot for the 33rd cluster

id	BMD.zSD	TF	trend
aars1_2.2	14.4	FALSE	inc
ahsa1a_1.3	4.5	FALSE	inc
anapc4_1.2	4.7	FALSE	inc
anapc5	23.6	FALSE	inc
btf3	27.6	FALSE	inc
btf3l4	25.6	FALSE	inc
ccnb1_1.2	24.6	FALSE	inc
ccne2_1.3	32.5	FALSE	inc
cdh1_1.2	4.4	FALSE	dec
cdk2	25.8	TRUE	inc
cdkn1ca	45.1	FALSE	inc
chd7_1.3	54.7	TRUE	dec
cnot1_2.1	39.6	FALSE	dec
ctc1	4.1	FALSE	inc
ddx6	22.0	FALSE	dec
dna2	34.7	FALSE	inc
dnm2a_1.2	2.2	FALSE	dec
drg1	24.8	FALSE	inc
drg2	34.2	FALSE	inc
edf1	44.6	TRUE	inc
eef1a1l1_1.2	29.8	FALSE	inc
eef1a1l1_1.3	49.8	FALSE	dec
eef1b2_1.1	39.3	FALSE	inc
eef1b2_1.2	39.5	FALSE	inc
eef1db_1.1	4.1	FALSE	inc
eef1db_1.5	32.1	FALSE	inc
eif2s1b	34.6	FALSE	inc
eif3ba	40.9	FALSE	inc
eif3d_1.4	30.9	FALSE	inc
eif3ea_1.3	5.4	FALSE	inc
eif3f	35.9	FALSE	inc
eif3g	28.0	FALSE	inc
eif3ha	40.4	FALSE	inc
eif3hb_1.2	44.7	FALSE	inc
eif3i	23.9	FALSE	inc
eif3jb	37.2	FALSE	dec
eif3k	44.3	FALSE	inc
eif3m	25.8	FALSE	inc
eif4e2	4.8	FALSE	inc
eif4ea_1.1	45.9	FALSE	dec
eif4ebp2	3.4	FALSE	dec
eif4enif1_1.3	32.6	FALSE	dec
eif5a2_1.2	3.0	FALSE	dec
eif5b_1.2	33.2	FALSE	dec
eri1_2.1	29.4	FALSE	inc
esco2	25.1	FALSE	inc
fabp3	38.4	FALSE	inc
faub_2.1	3.1	FALSE	U
furina_2.1	2.8	FALSE	dec
gemin2	32.3	FALSE	inc
gemin8_2.1	42.5	FALSE	dec
gins2	25.1	FALSE	inc
hdac4_1.2	34.3	TRUE	dec
hdac5_1.2	35.1	TRUE	dec
hmgn7_1.2	35.2	FALSE	inc
insrb	35.5	FALSE	dec
kcna4	58.2	FALSE	dec
kcnc3a_1.1	44.2	FALSE	dec
kras_1.2	37.2	FALSE	dec
mcm5	43.1	FALSE	inc
mcm7_1.2	43.1	FALSE	inc
mcm9	38.8	FALSE	inc
mcmbp	26.9	FALSE	inc
mcts1	27.2	FALSE	inc
mdka_1.1	3.3	FALSE	inc
mdka_1.2	46.7	FALSE	inc
mdka_1.4	32.5	FALSE	inc
meis1b_1.1	4.1	TRUE	inc
metap2a	40.2	FALSE	dec
metap2b	30.4	FALSE	dec
mrpl20	29.4	FALSE	inc
mrpl22	27.4	FALSE	inc
mrpl27	42.3	FALSE	inc
msi2b_1.6	4.1	FALSE	inc
msi2b_1.8	38.4	FALSE	dec
ndc80	20.1	FALSE	inc
ntn1a_1.2	39.4	FALSE	dec
orc4	28.9	FALSE	inc
pa2g4b_1.1	59.1	FALSE	inc
paics_1.1	3.1	FALSE	dec
pbx4_1.2	23.0	TRUE	dec
pdcd5	29.5	FALSE	inc
pin4	37.4	FALSE	inc
pitpnaa	3.1	FALSE	dec
pola2	37.8	FALSE	inc
pole2	30.9	FALSE	inc
pole4_1.3	2.6	FALSE	inc
prim2_1.2	30.3	FALSE	inc
puf60a_1.3	3.5	TRUE	inc
rack1_1.1	39.6	FALSE	inc
rack1_1.2	6.6	FALSE	inc
riok3	22.3	FALSE	inc
riox1	33.3	FALSE	inc
riox2	30.4	FALSE	inc
rnaseh2a_1.2	33.2	FALSE	inc
rpl10a_1.1	53.4	FALSE	inc
rpl11	41.9	FALSE	inc
rpl12_2.1	39.4	FALSE	inc
rpl13a	39.3	FALSE	inc
rpl14	6.9	FALSE	inc
rpl15	42.9	FALSE	inc
rpl17_1.1	4.6	FALSE	inc
rpl19	35.5	FALSE	inc
rpl23	43.8	FALSE	inc
rpl27	45.8	FALSE	inc
rpl28_1.2	2.1	FALSE	inc
rpl29	51.0	FALSE	inc
rpl3_1.2	7.8	FALSE	inc
rpl32_2.1	25.0	FALSE	inc
rpl35	8.2	FALSE	inc
rpl36a_1.3	46.0	FALSE	inc
rpl38	6.8	FALSE	inc
rpl39	42.0	FALSE	inc
rpl5a	9.0	FALSE	inc
rpl7	33.3	FALSE	inc
rpl7a_1.1	5.9	FALSE	inc
rpl8_1.2	4.6	FALSE	U
rpl9_1.1	7.0	FALSE	inc
rpl9_1.2	31.1	FALSE	inc
rplp0_1.2	6.2	FALSE	inc
rplp2	6.0	FALSE	inc
rps11	39.4	FALSE	inc
rps13_1.1	3.3	FALSE	dec
rps13_1.2	5.8	FALSE	inc
rps15	5.8	FALSE	inc
rps15a	47.0	FALSE	inc
rps18_1.2	28.2	FALSE	inc
rps2_1.1	42.6	FALSE	inc
rps2_1.2	25.0	FALSE	inc
rps24_1.1	3.4	FALSE	inc
rps26	6.6	FALSE	inc
rps27.1	29.3	FALSE	inc
rps27.2_1.2	32.1	FALSE	inc
rps27l	57.9	FALSE	inc
rps29	4.8	FALSE	inc
rps3a_1.1	42.5	FALSE	inc
rps5	8.7	FALSE	inc
rps6	36.0	FALSE	inc
rps7	7.9	FALSE	inc
rps8a	5.0	FALSE	inc
rps9_2.1	2.6	FALSE	inc
rpsa_1.2	59.0	FALSE	inc
rwdd1	31.5	FALSE	inc
sap130b_1.2	28.7	TRUE	dec
serbp1b	33.0	FALSE	dec
si:ch211-207d6.2	4.3	FALSE	dec
si:dkey-151g10.6	3.5	FALSE	inc
si:dkey-222b8.1_2.1	30.3	TRUE	dec
si:dkey-46g23.1_1.1	40.9	FALSE	dec
si:dkey-96n2.1	3.6	FALSE	inc
si:dkeyp-110a12.4	3.4	FALSE	inc
slc29a1a	40.8	FALSE	dec
snu13b	40.3	FALSE	inc
srp54	48.8	FALSE	inc
srpra	3.4	FALSE	dec
tfap2c_1.2	1.6	TRUE	dec
tnrc6c1_1.4	59.3	FALSE	dec
top1l	26.5	TRUE	dec
tpt1_1.1	24.9	FALSE	inc
utp6_3.1	39.3	FALSE	inc
ywhae2	37.9	FALSE	dec
znf622	4.2	TRUE	U

Figure 101: Table of the 33rd cluster content

Cluster 19 - 22 transcripts (~ 25% < 9.35 μg/L)

Driver GO terms : translational initiation

KEGG pathways : Herpes simplex virus 1 infection

Wikipathways :

Curvesplot

Figure 102: DR curves for the 34th cluster

BMDplot

Figure 103: BMDplot for the 34th cluster

id	BMD.zSD	TF	trend
akt3a_1.2	37.9	FALSE	dec
calr3b	4.1	FALSE	dec
cdc123_1.2	34.9	FALSE	inc
eif2b1_1.2	25.7	FALSE	inc
eif2b3_1.2	37.5	FALSE	inc
eif2b4_1.2	25.4	FALSE	inc
eif2b5	39.4	FALSE	inc
eif2s1b	34.6	FALSE	inc
eif2s2	40.6	FALSE	inc
eif2s3_1.3	29.3	FALSE	inc
eif4e2	4.8	FALSE	inc
eif4ea_1.1	45.9	FALSE	dec
eif4ebp2	3.4	FALSE	dec
eif4enif1_1.3	32.6	FALSE	dec
irf7_1.2	23.1	TRUE	inc
jak2a_1.1	44.0	FALSE	dec
pdia3_1.2	3.0	FALSE	dec
ptpn11a_1.2	3.1	FALSE	dec
pvrl2l	39.2	FALSE	dec
si:ch73-22o12.1	36.6	FALSE	dec
srsf5b_1.1	3.2	FALSE	bell
tapbp.1	35.7	FALSE	inc

Figure 104: Table of the 34th cluster content

Cluster 27 - 16 transcripts (~ 25% < 14.02 μg/L)

Driver GO terms : DNA repair

KEGG pathways : Fanconi anemia pathway

Wikipathways :

Curvesplot

Figure 105: DR curves for the 35th cluster

BMDplot

Figure 106: BMDplot for the 35th cluster

id	BMD.zSD	TF	trend
brca2	16.9	TRUE	inc
cenpn	32.1	FALSE	inc
cenps_2.1	34.1	FALSE	inc
faap100	36.9	FALSE	inc
fam168a_1.2	36.1	FALSE	dec
fan1_1.1	45.8	FALSE	inc
FO834799.1	5.2	FALSE	inc
nucks1a	39.3	FALSE	dec
palb2_1.2	1.7	FALSE	inc
rad51d	27.0	FALSE	inc
rbbp8_1.2	5.2	FALSE	inc
ube2a_1.2	4.9	FALSE	inc
ube2al	38.9	FALSE	inc
ube2t	41.3	FALSE	inc
unknown.76	24.1	FALSE	inc
usp1_1.2	23.8	FALSE	inc

Figure 107: Table of the 35th cluster content

Cluster 3 - 24 transcripts (~ 25% < 14.03 μg/L)

Driver GO terms : tRNA aminoacylation

KEGG pathways : Aminoacyl-tRNA biosynthesis

Wikipathways :

Curvesplot

Figure 108: DR curves for the 36th cluster

BMDplot

Figure 109: BMDplot for the 36th cluster

id	BMD.zSD	TF	trend
aars1_1.2	15.3	FALSE	inc
aars1_2.2	14.4	FALSE	inc
aimp1a	35.7	FALSE	inc
aimp1b_1.4	4.1	FALSE	inc
aimp2_1.2	38.0	FALSE	inc
dars1	17.8	FALSE	inc
dtd1	28.8	FALSE	inc
eprs1_1.2	15.4	FALSE	inc
farsa	16.2	FALSE	inc
farsb	12.4	FALSE	inc
gars1	39.3	FALSE	inc
hars_1.1	24.9	FALSE	inc
iars1	23.9	FALSE	inc
kars1_1.1	30.6	FALSE	inc
lars2_1.2	4.0	FALSE	U
LO017852.1	6.5	FALSE	inc
mars1_1.1	2.9	FALSE	inc
nars1	12.9	FALSE	inc
sars1	19.0	FALSE	inc
tars1_2.1	38.4	FALSE	inc
vars2	31.8	FALSE	inc
wars1	18.2	FALSE	inc
WARS1	39.5	FALSE	inc
yars1_1.2	22.2	FALSE	inc

Figure 110: Table of the 36th cluster content

Cluster 69 - 17 transcripts (~ 25% < 17.13 μg/L)

Driver GO terms :

KEGG pathways : Insulin signaling pathway

Wikipathways :

Curvesplot

Figure 111: DR curves for the 37th cluster

BMDplot

Figure 112: BMDplot for the 37th cluster

id	BMD.zSD	TF	trend
akt3a_1.2	37.9	FALSE	dec
braf_1.2	2.8	FALSE	bell
cbl	41.4	TRUE	dec
eif4e2	4.8	FALSE	inc
gnas_1.2	34.9	FALSE	dec
insrb	35.5	FALSE	dec
irs1	27.5	FALSE	dec
kras_1.2	37.2	FALSE	dec
pde3b	33.0	FALSE	dec
phkb_1.4	4.6	FALSE	inc
phkg1b_1.2	42.1	FALSE	inc
phkg2	4.6	FALSE	U
ppargc1a	37.8	TRUE	dec
ppp1r3cb_1.2	39.4	FALSE	inc
prkacaa	31.2	FALSE	dec
prkar1ab	31.9	FALSE	dec
prkar2aa	17.1	FALSE	dec

Figure 113: Table of the 37th cluster content

Cluster 23 - 20 transcripts (~ 25% < 21.79 μg/L)

Driver GO terms : DNA modification, methylation

KEGG pathways : Cysteine and methionine metabolism

Wikipathways :

Curvesplot

Figure 114: DR curves for the 38th cluster

BMDplot

Figure 115: BMDplot for the 38th cluster

id	BMD.zSD	TF	trend
adi1	28.8	FALSE	inc
apip	37.3	FALSE	inc
dnmt1	34.1	TRUE	inc
dnmt3aa_1.2	43.7	FALSE	dec
dnmt3ab_1.2	23.1	FALSE	dec
dnmt3bb.1_2.1	6.1	FALSE	dec
dnmt3bb.3_1.2	36.7	FALSE	inc
mto1	52.4	FALSE	inc
phgdh	17.9	FALSE	inc
prmt7_2.1	33.1	FALSE	inc
psat1	9.3	FALSE	inc
setd4	32.6	FALSE	inc
smyd1b_1.2	34.9	TRUE	inc
smyd4	37.1	FALSE	inc
tet3_1.2	43.3	FALSE	dec
tet3_1.3	2.3	FALSE	inc
thumpd3_2.1	31.2	FALSE	inc
trdmt1	37.8	FALSE	inc
trmt6	1.9	FALSE	U
vcpkmt_1.2	33.8	FALSE	inc

Figure 116: Table of the 38th cluster content

Cluster 42 - 24 transcripts (~ 25% < 22.31 μg/L)

Driver GO terms : DNA metabolic process

KEGG pathways : Base excision repair, DNA replication, Mismatch repair, Nucleotide excision repair

Wikipathways : DNA replication

Curvesplot

Figure 117: DR curves for the 39th cluster

BMDplot

Figure 118: BMDplot for the 39th cluster

id	BMD.zSD	TF	trend
brca2	16.9	TRUE	inc
ccdc36	4.5	FALSE	inc
cdca7a	31.7	FALSE	inc
cdk2	25.8	TRUE	inc
dna2	34.7	FALSE	inc
dnmt3bb.1_2.1	6.1	FALSE	dec
fam168a_1.2	36.1	FALSE	dec
fan1_1.1	45.8	FALSE	inc
hnrnpua	45.0	FALSE	dec
mnd1_1.2	52.5	FALSE	inc
nucks1a	39.3	FALSE	dec
palb2_1.2	1.7	FALSE	inc
rad17	32.9	FALSE	inc
rad51d	27.0	FALSE	inc
rbbp8_1.2	5.2	FALSE	inc
rfc2	33.5	FALSE	inc
rfc4_1.5	25.0	FALSE	inc
rfc5	34.3	FALSE	inc
rnaseh2a_1.2	33.2	FALSE	inc
top1_1.4	34.2	FALSE	dec
top1l	26.5	TRUE	dec
ube2a_1.2	4.9	FALSE	inc
ube2al	38.9	FALSE	inc
unknown.76	24.1	FALSE	inc

Figure 119: Table of the 39th cluster content

Cluster 47 - 4 transcripts (~ 25% < 22.88 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 120: DR curves for the 40th cluster

BMDplot

Figure 121: BMDplot for the 40th cluster

id	BMD.zSD	TF	trend
acta1b	28.8	FALSE	dec
cttn_1.2	5.2	FALSE	dec
scinla	33.2	FALSE	inc
shroom3_1.2	55.4	FALSE	dec

Figure 122: Table of the 40th cluster content

Cluster 67 - 5 transcripts (~ 25% < 23.12 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 123: DR curves for the 41st cluster

BMDplot

Figure 124: BMDplot for the 41st cluster

id	BMD.zSD	TF	trend
ppp1caa	23.1	FALSE	dec
ppp1cbl	36.0	FALSE	inc
ppp1r14aa	63.5	FALSE	inc
ppp1r7_1.1	43.0	FALSE	dec
ppp1r7_1.2	4.2	FALSE	inc

Figure 125: Table of the 41st cluster content

Cluster 4 - 80 transcripts (~ 25% < 23.78 μg/L)

Driver GO terms : respiratory electron transport chain, translation

KEGG pathways : Cardiac muscle contraction, Oxidative phosphorylation, Ribosome

Wikipathways : Electron transport chain, Oxidative phosphorylation

Curvesplot

Figure 126: DR curves for the 42nd cluster

BMDplot

Figure 127: BMDplot for the 42nd cluster

id	BMD.zSD	TF	trend
aars1_2.2	14.4	FALSE	inc
atp1a3a	58.6	FALSE	dec
atp2a1_1.1	43.0	FALSE	inc
atp2a2b	3.3	FALSE	dec
atp2a3_1.3	2.8	FALSE	dec
atp5f1c	24.5	FALSE	inc
CABZ01102240.1_1.1	4.2	FALSE	inc
cacng1a	30.6	FALSE	inc
cnot1_2.1	39.6	FALSE	dec
cox6b2	35.3	FALSE	inc
cox7a2a_1.2	38.4	FALSE	inc
ddx6	22.0	FALSE	dec
drg1	24.8	FALSE	inc
drg2	34.2	FALSE	inc
eef1a1l1_1.2	29.8	FALSE	inc
eef1a1l1_1.3	49.8	FALSE	dec
eif2s1b	34.6	FALSE	inc
eif4e2	4.8	FALSE	inc
eif4ea_1.1	45.9	FALSE	dec
eif4ebp2	3.4	FALSE	dec
eif4enif1_1.3	32.6	FALSE	dec
gfm2	2.8	FALSE	inc
gspt1	33.8	FALSE	inc
mettl17_1.4	39.9	FALSE	inc
mrpl15	52.5	FALSE	inc
mrpl20	29.4	FALSE	inc
mrpl22	27.4	FALSE	inc
mrpl27	42.3	FALSE	inc
mrpl3	39.8	FALSE	inc
mrpl30	34.5	FALSE	inc
mrpl4_1.2	36.5	FALSE	inc
mrpl42	40.8	FALSE	inc
mrpl43	36.3	FALSE	inc
mrpl45_2.2	31.9	FALSE	inc
mrps10	29.9	FALSE	inc
mrps15	30.5	FALSE	inc
mrps16_2.1	39.0	FALSE	inc
mrps18a	27.5	FALSE	inc
mrps18b	26.3	FALSE	inc
mrps18c	40.1	FALSE	inc
mrps22_1.4	41.8	FALSE	inc
msi2b_1.6	4.1	FALSE	inc
msi2b_1.8	38.4	FALSE	dec
mt-atp6	3.5	FALSE	inc
mt-atp8	34.3	FALSE	inc
mt-cyb	3.7	FALSE	inc
mt-nd1	30.2	FALSE	inc
mt-nd2	5.3	FALSE	inc
mt-nd3	4.3	FALSE	inc
mt-nd4	3.5	FALSE	inc
mt-nd4l	29.3	FALSE	inc
mt-nd5	6.9	FALSE	U
mt-nd6	3.6	FALSE	inc
ndufaf3	31.1	FALSE	inc
ndufaf5	41.4	FALSE	inc
ndufb11	33.8	FALSE	inc
ndufb5	40.9	FALSE	inc
ndufb6	26.8	FALSE	inc
ndufb8	32.8	FALSE	inc
ndufb9	39.6	FALSE	inc
ndufs2	40.9	FALSE	inc
pmpcb	24.4	FALSE	inc
postnb_1.4	7.0	FALSE	inc
ppa1b	29.1	FALSE	inc
rpl32_2.1	25.0	FALSE	inc
rpl36a_1.3	46.0	FALSE	inc
rpl7a_1.1	5.9	FALSE	inc
rps9_2.1	2.6	FALSE	inc
rwdd1	31.5	FALSE	inc
sdhb	40.8	FALSE	inc
sdhc_1.2	29.1	FALSE	inc
si:ch211-139a5.9_1.1	29.7	FALSE	inc
si:dkey-151g10.6	3.5	FALSE	inc
si:dkey-46g23.1_1.1	40.9	FALSE	dec
slc25a55b	39.0	FALSE	dec
slc8a2b	47.0	FALSE	dec
soul4	49.9	FALSE	dec
tnrc6c1_1.4	59.3	FALSE	dec
trdn_1.4	57.1	FALSE	dec
ucp2	53.2	FALSE	inc

Figure 128: Table of the 42nd cluster content

Cluster 65 - 4 transcripts (~ 25% < 23.82 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 129: DR curves for the 43rd cluster

BMDplot

Figure 130: BMDplot for the 43rd cluster

id	BMD.zSD	TF	trend
acin1a_1.1	43	FALSE	inc
luc7l3	36	FALSE	dec
pnisr_1.2	6	FALSE	bell
pnn	30	FALSE	dec

Figure 131: Table of the 43rd cluster content

Cluster 46 - 17 transcripts (~ 25% < 24.59 μg/L)

Driver GO terms : DNA replication

KEGG pathways : DNA replication, Fanconi anemia pathway, Homologous recombination, Mismatch repair, Nucleotide excision repair

Wikipathways : DNA replication, G1 to S cell cycle control

Curvesplot

Figure 132: DR curves for the 44th cluster

BMDplot

Figure 133: BMDplot for the 44th cluster

id	BMD.zSD	TF	trend
brca2	16.9	TRUE	inc
ccnb1_1.2	24.6	FALSE	inc
ccne2_1.3	32.5	FALSE	inc
cdk2	25.8	TRUE	inc
cdkn1ca	45.1	FALSE	inc
dna2	34.7	FALSE	inc
palb2_1.2	1.7	FALSE	inc
rad51d	27.0	FALSE	inc
rad54l	22.3	FALSE	inc
rbbp8_1.2	5.2	FALSE	inc
recql4	31.7	FALSE	inc
rnaseh2a_1.2	33.2	FALSE	inc
rpa1	48.3	FALSE	inc
rpa2_1.2	43.2	FALSE	inc
rpa3	30.9	FALSE	inc
top1l	26.5	TRUE	dec
top3b	28.0	FALSE	dec

Figure 134: Table of the 44th cluster content

Cluster 61 - 6 transcripts (~ 25% < 24.94 μg/L)

Driver GO terms :

KEGG pathways : ATP-dependent chromatin remodeling

Wikipathways :

Curvesplot

Figure 135: DR curves for the 45th cluster

BMDplot

Figure 136: BMDplot for the 45th cluster

id	BMD.zSD	TF	trend
chd3_2.2	30.4	TRUE	dec
chrac1_1.2	25.0	TRUE	inc
gatad2b	24.9	TRUE	dec
lin52_1.2	44.3	FALSE	inc
rbbp4	36.7	TRUE	inc
smarcb1b_1.3	2.9	FALSE	inc

Figure 137: Table of the 45th cluster content

Cluster 6 - 27 transcripts (~ 25% < 24.96 μg/L)

Driver GO terms : ribosome biogenesis

KEGG pathways : Ribosome biogenesis in eukaryotes

Wikipathways :

Curvesplot

Figure 138: DR curves for the 46th cluster

BMDplot

Figure 139: BMDplot for the 46th cluster

id	BMD.zSD	TF	trend
aamp_1.2	27.2	FALSE	inc
bms1_2.1	2.9	FALSE	dec
emg1	48.1	FALSE	inc
eri1_2.1	29.4	FALSE	inc
exosc5_1.1	5.2	FALSE	dec
exosc5_1.2	40.4	FALSE	inc
exosc8	31.8	FALSE	inc
glmna	34.4	FALSE	inc
ncoa6_1.2	2.5	FALSE	inc
ncoa6_1.3	32.4	FALSE	dec
ngdn	42.8	FALSE	inc
nmd3	48.1	FALSE	inc
noc4l	43.0	FALSE	inc
nop58	2.6	FALSE	dec
pin4	37.4	FALSE	inc
pno1	22.7	FALSE	inc
rab5if	2.3	FALSE	dec
ran	30.5	TRUE	inc
rpl7a_1.1	5.9	FALSE	inc
rrp7a	39.9	FALSE	inc
snu13b	40.3	FALSE	inc
trub2	31.9	FALSE	inc
UTP14C	52.0	FALSE	dec
utp6_3.1	39.3	FALSE	inc
xrn1	35.5	FALSE	dec
xrn2_1.2	28.1	TRUE	dec
zgc:174888_1.2	33.9	FALSE	inc

Figure 140: Table of the 46th cluster content

Cluster 28 - 5 transcripts (~ 25% < 25.16 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 141: DR curves for the 47th cluster

BMDplot

Figure 142: BMDplot for the 47th cluster

id	BMD.zSD	TF	trend
actr8	44.5	TRUE	inc
dsn1	29.9	FALSE	inc
knl1	2.1	FALSE	inc
si:dkey-6i22.5	31.2	FALSE	inc
spc24	25.2	FALSE	inc

Figure 143: Table of the 47th cluster content

Cluster 40 - 10 transcripts (~ 25% < 26.62 μg/L)

Driver GO terms : regulatory ncRNA-mediated gene silencing

KEGG pathways :

Wikipathways :

Curvesplot

Figure 144: DR curves for the 48th cluster

BMDplot

Figure 145: BMDplot for the 48th cluster

id	BMD.zSD	TF	trend
ago1	40.2	TRUE	dec
ago2	28.4	TRUE	dec
ago4	54.4	FALSE	dec
dicer1_1.1	26.0	FALSE	dec
eri1_2.1	29.4	FALSE	inc
pum1_1.2	34.1	FALSE	dec
si:dkey-46g23.1_1.1	40.9	FALSE	dec
snd1_1.2	2.3	TRUE	dec
tarbp2	24.4	FALSE	dec
tnrc6c1_1.4	59.3	FALSE	dec

Figure 146: Table of the 48th cluster content

Cluster 63 - 18 transcripts (~ 25% < 26.73 μg/L)

Driver GO terms :

KEGG pathways : Apelin signaling pathway

Wikipathways :

Curvesplot

Figure 147: DR curves for the 49th cluster

BMDplot

Figure 148: BMDplot for the 49th cluster

id	BMD.zSD	TF	trend
akt3a_1.2	37.9	FALSE	dec
aplnr2	6.9	FALSE	inc
cdh1_1.2	4.4	FALSE	dec
gna11b	39.7	FALSE	dec
gnai2a	4.1	FALSE	dec
gnb1a	56.9	FALSE	dec
gnb1b	30.4	FALSE	dec
hdac4_1.2	34.3	TRUE	dec
hdac5_1.2	35.1	TRUE	dec
kras_1.2	37.2	FALSE	dec
mef2cb_1.5	41.3	TRUE	dec
mef2d_1.2	41.0	TRUE	dec
mylkb_1.2	2.9	FALSE	dec
pde3b	33.0	FALSE	dec
ppargc1a	37.8	TRUE	dec
si:dkey-222b8.1_2.1	30.3	TRUE	dec
slc8a2b	47.0	FALSE	dec
tfam	25.5	TRUE	inc

Figure 149: Table of the 49th cluster content

Cluster 51 - 4 transcripts (~ 25% < 26.86 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Curvesplot

Figure 150: DR curves for the 50th cluster

BMDplot

Figure 151: BMDplot for the 50th cluster

id	BMD.zSD	TF	trend
fam214a_2.1	40	FALSE	dec
pak1ip1	24	FALSE	inc
rsl24d1	33	FALSE	inc
wdr18	28	FALSE	inc

Figure 152: Table of the 50th cluster content